Evidence map›Paper›PMID 17931676›Full record

ArticleVirology2008

Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein.

Kelly-Anne Spencer, Michael Dee, Paul Britton, Julian A Hiscox

Open access · greenAbstract read
In one paragraph

Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  3. Review
  4. Classification, replication, and transcription ofFrontiers in microbiology · 2023
    Review
  5. Article
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  7. Article
  8. Article
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  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kelly-Anne SpencerInstitute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Michael Dee
Paul Britton
Julian A Hiscox
The Pirbright Institute · GBUniversity of Leeds · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00001256
6 · The paper itself

Abstract

The coronavirus infectious bronchitis virus (IBV) nucleocapsid (N) protein is an RNA binding protein which is phosphorylated at two conserved clusters. Kinetic analysis of RNA binding indicated that the C-terminal phosphorylation cluster was involved in the recognition of viral RNA from non-viral RNA. The IBV N protein has been found to be essential for the successful recovery of IBV using reverse genetics systems. Rescue experiments indicated that phosphorylated N protein recovered infectious IBV more efficiently when compared to modified N proteins either partially or non-phosphorylated. Our data indicate that the phosphorylated form of the IBV N protein plays a role in virus biology.

Indexed as

AnimalsBase SequenceBinding SitesCell LineCoronavirus Nucleocapsid ProteinsInfectious bronchitis virusKineticsNucleocapsid ProteinsPhosphorylationRecombinant ProteinsRNA-Binding ProteinsRNA, ViralSpodopteraCoronavirus Nucleocapsid ProteinsNucleocapsid ProteinsRecombinant ProteinsRNA-Binding ProteinsRNA, Viral

Identifiers

PMID17931676
PMCPMC7103301
OpenAlexW1978492897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.