ArticleEnvironmental health : a global access science source2007
Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study.
Article in Environmental health : a global access science source, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 199 citations in OpenAlex.
- Perinatal death and exposure to dental amalgam fillings during pregnancy in the population-based MoBa cohort.PloS one · 2018Trial
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- A Novel DLLME-Based Approach for the Spectrophotometric Determination of Mercury in Environmental Samples Using the Fe(II) Phthalocyanine Sensor.Molecules (Basel, Switzerland) · 2025Article
- Assessment of total mercury (Hg) in soil, sediment, and tilapia fish (Oreochromis niloticus) and health risk assessment among residents of Kitwe mining area, Zambia.Environmental science and pollution research international · 2025Article
- DNA Sensors for the Detection of Mercury Ions.Biosensors · 2025Review
- Concerning Mercury (Hg) Levels in the Hair of Children Inhabiting a Volcanically Active Area.Toxics · 2025Article
- Heavy Metal Exposure-induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants.Current medicinal chemistry · 2025Review
- Health complaints before and at one and five years after removal of dental amalgam restorations - data from a prospective cohort study in Norway.Acta odontologica Scandinavica · 2024Article
- What does scientometry tell us about mercury toxicology and its biological impairments?Heliyon · 2024Article
- Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture.Molecular neurobiology · 2023Article
- Determination by ICP-MS of Essential and Toxic Trace Elements in Gums and Carrageenans Used as Food Additives Commercially Available in the Portuguese Market.Foods (Basel, Switzerland) · 2023Article
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- The association between the urinary biomarkers of polycyclic aromatic hydrocarbons and risk of metabolic syndromes and blood cell levels in adults in a Middle Eastern area.Journal of environmental health science & engineering · 2021Article
- Assessment of Hg accumulation in fish and scalp hair in fishing communities along river Swat, Pakistan.Environmental science and pollution research international · 2021Article
- BMAA, Methylmercury, and Mechanisms of Neurodegeneration in Dolphins: A Natural Model of Toxin Exposure.Toxins · 2021Article
- Article
- Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012-2014.International journal of environmental research and public health · 2021Article
- Direct Mercury Detection in Landfill Leachate Using a Novel AuNP-Biopolymer Carbon Screen-Printed Electrode Sensor.Micromachines · 2021Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe main forms of mercury (Hg) exposure in the general population are methylmercury (MeHg) from seafood, inorganic mercury (I-Hg) from food, and mercury vapor (Hg0) from dental amalgam restorations. While the distribution of MeHg in the body is described by a one compartment model, the distribution of I-Hg after exposure to elemental mercury is more complex, and there is no biomarker for I-Hg in the brain. The aim of this study was to elucidate the relationships between on the one hand MeHg and I-Hg in human brain and other tissues, including blood, and on the other Hg exposure via dental amalgam in a fish-eating population. In addition, the use of blood and toenails as biological indicator media for inorganic and organic mercury (MeHg) in the tissues was evaluated.
methodsSamples of blood, brain (occipital lobe cortex), pituitary, thyroid, abdominal muscle and toenails were collected at autopsy of 30 deceased individuals, age from 47 to 91 years of age. Concentrations of total-Hg and I-Hg in blood and brain cortex were determined by cold vapor atomic fluorescence spectrometry and total-Hg in other tissues by sector field inductively coupled plasma-mass spectrometry (ICP-SFMS).
resultsThe median concentrations of MeHg (total-Hg minus I-Hg) and I-Hg in blood were 2.2 and 1.0 microg/L, and in occipital lobe cortex 4 and 5 microg/kg, respectively. There was a significant correlation between MeHg in blood and occipital cortex. Also, total-Hg in toenails correlated with MeHg in both blood and occipital lobe. I-Hg in both blood and occipital cortex, as well as total-Hg in pituitary and thyroid were strongly associated with the number of dental amalgam surfaces at the time of death.
conclusionIn a fish-eating population, intake of MeHg via the diet has a marked impact on the MeHg concentration in the brain, while exposure to dental amalgam restorations increases the I-Hg concentrations in the brain. Discrimination between mercury species is necessary to evaluate the impact on Hg in the brain of various sources of exposure, in particular, dental amalgam exposure.
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