ArticleJournal of neurochemistry2007
Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.
Article in Journal of neurochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.eLife · 2021Article
- Metabolic modulation of neuronal gamma-band oscillations.Pflugers Archiv : European journal of physiology · 2018Article
- Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism.The Journal of cell biology · 2018Review
- Bioenergetic Mechanisms of Seizure Control.Frontiers in cellular neuroscience · 2018Review
- A Metabolic Therapy for Malignant Glioma Requires a Clinical Measure.Current oncology reports · 2017Review
- Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.Journal of neuroinflammation · 2017Article
- Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex.International journal of molecular sciences · 2017Article
- A neuronal lactate uptake inhibitor slows recovery of extracellular ion concentration changes in the hippocampal CA3 region by affecting energy metabolism.Journal of neurophysiology · 2016Article
- Fatty Acid Biosynthesis Inhibition Increases Reduction Potential in Neuronal Cells under Hypoxia.Frontiers in neuroscience · 2016Article
- Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro.Neurobiology of disease · 2015Article
- Age-related metabolic fatigue during low glucose conditions in rat hippocampus.Neurobiology of aging · 2015Article
- The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis.Cell regeneration (London, England) · 2015Article
- Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells.BioMed research international · 2014Article
- Energy substrates that fuel fast neuronal network oscillations.Frontiers in neuroscience · 2014Article
- Unraveling the complex metabolic nature of astrocytes.Frontiers in cellular neuroscience · 2013Review
- Exploiting metabolic differences in glioma therapy.Current drug discovery technologies · 2012Review
- Brain lactate metabolism: the discoveries and the controversies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Cellular Links between Neuronal Activity and Energy Homeostasis.Frontiers in pharmacology · 2012Article
- Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation.Neurobiology of disease · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Synaptic train stimulation (10 Hz x 25 s) in hippocampal slices results in a biphasic response of NAD(P)H fluorescence indicating a transient oxidation followed by a prolonged reduction. The response is accompanied by a transient tissue PO(2) decrease indicating enhanced oxygen utilization. The activation of mitochondrial metabolism and/or glycolysis may contribute to the secondary NAD(P)H peak. We investigated whether extracellular lactate uptake via monocarboxylate transporters (MCTs) contributes to the generation of the NAD(P)H response during neuronal activation. We measured the effect of lactate uptake inhibition [using the MCT inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN)] on the NAD(P)H biphasic response, tissue PO(2) response, and field excitatory post-synaptic potential in hippocampal slices during synaptic stimulation in area CA1 (stratum radiatum). The application of 4-CIN (150-250 micromol/L) significantly decreased the reduction phase of the NAD(P)H response. When slices were supplemented with 20 mmol/L lactate in 150-250 micromol/L 4-CIN, the secondary NAD(P)H peak was restored; whereas 20 mmol/L pyruvate supplementation did not produce a recovery. Similarly, the tissue PO(2) response was decreased by MCT inhibition; 20 mmol/L lactate restored this response to control levels at all 4-CIN concentrations. These results indicate that lactate uptake via MCTs contributes significantly to energy metabolism in brain tissue and to the generation of the delayed NAD(P)H peak after synaptic stimulation.
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