ArticleHistochemistry and cell biology2008
Induction of peroxisomal Lon protease in rat liver after di-(2-ethylhexyl)phthalate treatment.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight.International journal of molecular sciences · 2022Review
- Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Physiological reviews · 2018Review
- The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1.Biological reviews of the Cambridge Philosophical Society · 2017Review
- From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals.Frontiers in physiology · 2017Review
- Autophagic degradation of peroxisomes in mammals.Biochemical Society transactions · 2016Review
- Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives.Frontiers in physiology · 2013Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Pexophagy: the selective degradation of peroxisomes.International journal of cell biology · 2012Article
- Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.The Journal of biological chemistry · 2011Article
- Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms.Histochemistry and cell biology · 2009Review
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we identified a peroxisome-specific isoform of Lon protease using subcellular proteomics. In the present study, we investigated changes in the level of the Lon protease in peroxisomes during recovery from peroxisomal proliferation induced by di-(2-ethylhexyl)phthalate (DEHP) to elucidate the function of peroxisomal Lon protease (PSLP). Following a 2-week treatment with DEHP, the level of PSLP was monitored for 15 days. The amount of protease was greatly increased after the 2-week treatment, followed by a further increase 3 days after cessation of the treatment. Afterward, it decreased and reached the control level on day 15. On the other hand, level peroxisomal beta-oxidation enzymes induced to express by DEHP started to decrease soon after discontinuation of treatment. The results suggest that PSLP functions to degrade beta-oxidation enzymes induced by DEHP during recovery from perxisomal proliferation.
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