Trial reportDiabetologia2007
Lowering serum urate does not improve endothelial function in patients with type 2 diabetes.
Trial report in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double-blind, crossover study.Physiological reports · 2021Trial
- Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.Journal of the American Heart Association · 2019Trial
- Impact of diabetes on the association between serum urate levels and incident dementia: a cohort study in the UK biobank.The journal of nutrition, health & aging · 2024Article
- Clinical Implications of Uric Acid in Heart Failure: A Comprehensive Review.Life (Basel, Switzerland) · 2021Review
- Mendelian randomization study of serum uric acid levels and diabetes risk: evidence from the Dongfeng-Tongji cohort.BMJ open diabetes research & care · 2020Observational
- Uric Acid and Arterial Stiffness.Therapeutics and clinical risk management · 2020Review
- Hyperuricemia and Hypertension: Links and Risks.Integrated blood pressure control · 2019Review
- Serum Uric Acid Is Associated with Erectile Dysfunction: A Population-Based Cross-Sectional Study in Chinese Men.Scientific reports · 2017Article
- Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta-analysis.Chronic diseases and translational medicine · 2016Article
- Urate reduction and renal preservation: what is the evidence?Current rheumatology reports · 2013Review
- The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality.BMC nephrology · 2013Review
- Are either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisal.Arthritis and rheumatism · 2012Review
- The role of serum uric acid in cardiovascular disease in type 2 diabetic and non-diabetic subjects: a narrative review.Journal of endocrinological investigation · 2011Review
- Determinants of vascular function in patients with chronic gout.Journal of clinical hypertension (Greenwich, Conn.) · 2011Article
- Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats.The Journal of pharmacology and experimental therapeutics · 2010Article
- Uric acid and antioxidant effects of wine.Croatian medical journal · 2010Review
- The dual effect of uric acid on the burning endothelium: gasoline or water?Internal and emergency medicine · 2009Article
- Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?Endocrine reviews · 2009Review
- Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress.Vascular health and risk management · 2009Review
- Uric acid and cardiovascular risk.The New England journal of medicine · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisEndothelial dysfunction contributes to excess cardiovascular risk in patients with type 2 diabetes. There is strong evidence of an association between high serum uric acid concentrations and endothelial dysfunction, and uric acid has been proposed as an independent cardiovascular risk factor in type 2 diabetes. We hypothesised that lowering of uric acid concentrations might allow restoration of endothelial function in this high-risk group.
methodsIntravenous urate oxidase (1.5 mg) was administered to ten patients with type 2 diabetes and ten healthy participants in a two-way, randomised, placebo-controlled, crossover study. Forearm blood flow responses to intra-brachial acetylcholine, sodium nitroprusside and N(G)-monomethyl-L-arginine (L-NMMA) were measured using venous occlusion plethysmography. The augmentation index (AIx) was determined by pulse wave analysis as a measure of large arterial stiffness.
resultsAcetylcholine and L-NMMA evoked lesser responses in patients with type 2 diabetes than in healthy participants. Baseline AIx was higher in patients with type 2 diabetes (mean +/- SD: 13.1 +/- 6.9%) than in healthy participants (2.0 +/- 5.1%; p = 0.006). Urate oxidase lowered serum uric acid concentrations by 64 +/- 11% (p < 0.001), but this had no effect on forearm blood flow responses or AIx in either group. CONCLUSIONS/
interpretationSubstantial short-term lowering of uric acid did not have a direct vascular effect, suggesting that, on its own, this might not be an effective strategy for restoring endothelial function in patients with type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.