ArticleGenes and immunity2008
Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancer.NPJ digital medicine · 2025Article
- The Relationship Between Soluble Interleukin-17 Receptor Levels and CD3-Positive T Cells and Lymphocytes in Patients with Sepsis and Their Predictive Clinical Significance.Journal of inflammation research · 2024Article
- Mouse monocytes express CD127 by immune cells, not LPS.Frontiers in immunology · 2024Article
- A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells.Frontiers in immunology · 2024Article
- The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy.International journal of molecular sciences · 2022Review
- Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.Frontiers in immunology · 2020Review
- Regenerating Immunotolerance in Multiple Sclerosis with Autologous Hematopoietic Stem Cell Transplant.Frontiers in immunology · 2018Review
- Interleukin-7 and Immunosenescence.Journal of immunology research · 2017Review
- Article
- Targeting Homeostatic T Cell Proliferation to Control Beta-Cell Autoimmunity.Current diabetes reports · 2016Review
- A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis.Journal of immunology research · 2016Article
- Investigating Factors Associated with Thymic Regeneration after Chemotherapy in Patients with Lymphoma.Frontiers in immunology · 2016Article
- The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation.International journal of molecular sciences · 2015Review
- Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies.Journal of molecular biology · 2015Article
- IL7R gene expression network associates with human healthy ageing.Immunity & ageing : I & A · 2015Article
- Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients.Intensive care medicine · 2014Article
- The promoter SNP, but not the alternative splicing SNP, is linked to multiple sclerosis among Jordanian patients.Journal of molecular neuroscience : MN · 2014Article
- Interleukin-7 and type 1 diabetes.Current diabetes reports · 2014Review
- IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Genes and immunity · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple sclerosis (MS), especially primary progressive MS (PPMS). We demonstrate that two CD127 haplotypes are highly associated with the proportion of the mRNA encoding the soluble isoform of CD127 (P<or=0.001). The soluble isoform is over-represented (P<or=0.002) in PPMS peripheral blood, irrespective of haplotype, and the MS susceptibility haplotype produces more of the soluble isoform. CD127 mRNA is underexpressed (P<or=0.001) in PPMS. Neutrophils, which produce very low levels of CD127 mRNA, were over-represented in our PPMS cohort (P<0.02). CD127 expression is lower in more differentiated cells, such as Th1s, which can be elevated in MS. A higher proportion of these two abundant cell types in peripheral blood could be the basis for the observed reduction in CD127 mRNA. CD127 expression may be a biomarker for these potentially pathologically significant leukocyte types. These significant haplotypic effects on expression are likely to modulate regulation, differentiation and function of T cell subsets in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.