ArticleMolecular biology of the cell2007
Acclimation of Saccharomyces cerevisiae to low temperature: a chemostat-based transcriptome analysis.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 118 citations in OpenAlex.
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- Exploring adaptation routes to cold temperatures in the Saccharomyces genus.PLoS genetics · 2025Article
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- Improving expression and assembly of difficult-to-express heterologous proteins in Saccharomyces cerevisiae by culturing at a sub-physiological temperature.Microbial cell factories · 2023Article
- Novel Antarctic yeast adapts to cold by switching energy metabolism and increasing small RNA synthesis.The ISME journal · 2022Article
- Temperature affects the repeatability of evolution in the microbial eukaryoteEcology and evolution · 2021Article
- Yeast Fermentation at Low Temperatures: Adaptation to Changing Environmental Conditions and Formation of Volatile Compounds.Molecules (Basel, Switzerland) · 2021Review
- Chromosome Genome Sequencing and Comparative Transcriptome-Based Analyses ofFrontiers in microbiology · 2021Article
- Differential proteomic analysis by SWATH-MS unravels the most dominant mechanisms underlying yeast adaptation to non-optimal temperatures under anaerobic conditions.Scientific reports · 2020Article
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- Selection and subsequent physiological characterization of industrialBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Time-Course Transcriptome ofInternational journal of molecular sciences · 2020Article
- Temperature preference can bias parental genome retention during hybrid evolution.PLoS genetics · 2019Article
- Rapid Identification of Major QTLFrontiers in microbiology · 2018Article
- Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids.Microbial cell factories · 2017Article
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- Novel brewing yeast hybrids: creation and application.Applied microbiology and biotechnology · 2017Review
- Genomic, Transcriptomic, and Proteomic Analysis Provide Insights Into the Cold Adaptation Mechanism of the Obligate Psychrophilic FungusG3 (Bethesda, Md.) · 2016Article
- Cold Temperature Induces the Reprogramming of Proteolytic Pathways in Yeast.The Journal of biological chemistry · 2016Article
- Genome-Wide Transcriptional Response of Saccharomyces cerevisiae to Stress-Induced Perturbations.Frontiers in bioengineering and biotechnology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of suboptimal temperatures on transcriptional regulation in yeast have been extensively studied in batch cultures. To eliminate indirect effects of specific growth rates that are inherent to batch-cultivation studies, genome-wide transcriptional responses to low temperatures were analyzed in steady-state chemostats, grown at a fixed specific growth rate (0.03 h(-1)). Although in vivo metabolic fluxes were essentially the same in cultures grown at 12 and at 30 degrees C, concentrations of the growth-limiting nutrients (glucose or ammonia) were higher at 12 degrees C. This difference was reflected by transcript levels of genes that encode transporters for the growth-limiting nutrients. Several transcriptional responses to low temperature occurred under both nutrient-limitation regimes. Increased transcription of ribosome-biogenesis genes emphasized the importance of adapting protein-synthesis capacity to low temperature. In contrast to observations in cold-shock and batch-culture studies, transcript levels of environmental stress response genes were reduced at 12 degrees C. Transcription of trehalose-biosynthesis genes and intracellular trehalose levels indicated that, in contrast to its role in cold-shock adaptation, trehalose is not involved in steady-state low-temperature adaptation. Comparison of the chemostat-based transcriptome data with literature data revealed large differences between transcriptional reprogramming during long-term low-temperature acclimation and the transcriptional responses to a rapid transition to low temperature.
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