Evidence map›Paper›PMID 17928346›Full record

ReviewJournal of virology2008

Viral and host factors in human respiratory syncytial virus pathogenesis.

Peter L Collins, Barney S Graham

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04934111 (A Clinical Trial to Assess the Safety and Immunogenicity of LNP-nCOV saRNA-02, a Self-amplifying Ribonucleic Acid), which is not on this map. Cited by 284 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04934111 phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

A Clinical Trial to Assess the Safety and Immunogenicity of LNP-nCOV saRNA-02, a Self-amplifying Ribonucleic Acid (saRNA) Vaccine, in SARS-CoV-2 Seronegative and Seropositive Uganda Population

TypeinterventionalSponsorMRC/UVRI and LSHTM Uganda Research UnitRan2021 to 2022Enrolled42ConditionsCOVID-19ArmsLNP-nCOV saRNA-02 Vaccine
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Special Issue "Antiviral Drugs Discovery".International journal of molecular sciences · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Prophylactic monoclonal antibodies against respiratory syncytial virus in early life: An in-depth review of mechanisms of action, failure factors, and future perspectives.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  17. Organoids: physiologically relevantJournal of virology · 2025
    Review
  18. Article
  19. Review
  20. Article

224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter L CollinsNIAID, NIH, 50 South Drive, MSC 8007, Bethesda, MD 20892, USA. pcollins@niaid.nih.gov
Barney S Graham

Funding

Laboratory Studies of Human Respiratory Syncytial Virus and Other PneumovirusesZIAAI000372 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BUCHHOLZ, URSULA · 2009 to 2025
$21.8M
RSV PROTEINS--ROLES IN HOST IMMUNITY AND IMMUNOPROPHYLAXISZ01AI000372 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI COLLINS, PETER LEON · 1985 to 2008
$11.0M
Cytolytic T Cell Activity In Response To Primary RSV Infection In MiceZIAAI005027 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GRAHAM, BARNEY · 2009 to 2021
$10.3M
Factors Contributing To Immune-Enhanced Disease In The Pathogenesis of RSVZIAAI005029 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GRAHAM, BARNEY · 2009 to 2017
$6.2M
Production And Characterization Of HIV-1 Solid Phase ProZ01AI005027 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI GRAHAM, BARNEY SCOTT · 2002 to 2008
$1.4M
Immune-enhanced Disease In the Pathogenesis of RSVZ01AI005029 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI GRAHAM, BARNEY SCOTT · 2002 to 2008
$1.4M
Intramural NIH HHS
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HumansRespiratory Syncytial VirusesRespiratory Syncytial Virus Infections

Identifiers

PMID17928346
PMCPMC2258918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.