ArticleJournal of virology2007
Discrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirus.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 84 citations in OpenAlex.
- Inter-regulatory role of microRNAs in interaction between viruses and stem cells.World journal of stem cells · 2021Review
- The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding.Pathogens (Basel, Switzerland) · 2021Article
- Mapping the Human Herpesvirus 6B transcriptome.Journal of virology · 2021Article
- Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells.Frontiers in microbiology · 2021Review
- MicroRNAs expressed by human cytomegalovirus.Virology journal · 2020Review
- Article
- HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation.Non-coding RNA · 2018Review
- Please stand by: how oncolytic viruses impact bystander cells.Future virology · 2018Review
- Integrated analysis of mRNA and viral miRNAs in the kidney of Carassius auratus gibelio response to cyprinid herpesvirus 2.Scientific reports · 2017Article
- Herpesviral microRNAs in Cellular Metabolism and Immune Responses.Frontiers in microbiology · 2017Review
- Identification and Characterization of Cyprinid Herpesvirus-3 (CyHV-3) Encoded MicroRNAs.PloS one · 2015Article
- Cytomegalovirus microRNAs.Current opinion in virology · 2014Review
- Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.PLoS neglected tropical diseases · 2014Article
- Human cytomegalovirus-encoded miR-US25-1 aggravates the oxidised low density lipoprotein-induced apoptosis of endothelial cells.BioMed research international · 2014Article
- Molecular investigation of the 7.2 kb RNA of murine cytomegalovirus.Virology journal · 2013Article
- Functional genomics approaches to understand cytomegalovirus replication, latency and pathogenesis.Current opinion in virology · 2013Review
- Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo.Virology · 2012Article
- Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.PLoS pathogens · 2012Article
- Small RNA deep sequencing identifies microRNAs and other small noncoding RNAs from human herpesvirus 6B.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The prevalence and importance of microRNAs (miRNAs) in viral infection are increasingly relevant. Eleven miRNAs were previously identified in human cytomegalovirus (HCMV); however, miRNA content in murine CMV (MCMV), which serves as an important in vivo model for CMV infection, has not previously been examined. We have cloned and characterized 17 novel miRNAs that originate from at least 12 precursor miRNAs in MCMV and are not homologous to HCMV miRNAs. In parallel, we applied a computational analysis, using a support vector machine approach, to identify potential precursor miRNAs in MCMV. Four of the top 10 predicted precursor sequences were cloned in this study, and the combination of computational and cloning analysis demonstrates that MCMV has the capacity to encode miRNAs clustered throughout the genome. On the basis of drug sensitivity experiments for resolving the kinetic class of expression, we show that the MCMV miRNAs are both early and late gene products. Notably, the MCMV miRNAs occur on complementary strands of the genome in specific regions, a feature which has not previously been observed for viral miRNAs. One cluster of miRNAs occurs in close proximity to the 5' splice site of the previously identified 7.2-kb stable intron, implying a variety of potential regulatory mechanisms for MCMV miRNAs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.