ArticleTuberculosis (Edinburgh, Scotland)2008
Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro.
Article in Tuberculosis (Edinburgh, Scotland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis.Nature communications · 2020Article
- Ribosomal maturation factor (RimP) is essential for survival of nontuberculous mycobacteria3 Biotech · 2019Article
- Using diphenyleneiodonium to induce a viable but non-culturable phenotype in Mycobacterium tuberculosis and its metabolomics analysis.PloS one · 2019Article
- Superoxide Generation and Its Involvement in the Growth ofFrontiers in microbiology · 2017Article
- Comparative Genomic Analysis Reveals a Possible Novel Non-Tuberculous Mycobacterium Species with High Pathogenic Potential.PloS one · 2016Article
- Impact of Hypoxia on Drug Resistance and Growth Characteristics of Mycobacterium tuberculosis Clinical Isolates.PloS one · 2016Article
- Redox homeostasis in mycobacteria: the key to tuberculosis control?Expert reviews in molecular medicine · 2011Review
- Article
- The response of mycobacterium tuberculosis to reactive oxygen and nitrogen species.Frontiers in microbiology · 2011Article
- Reprogramming theDrug discovery today. Disease mechanisms · 2010Article
- Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model.Tuberculosis (Edinburgh, Scotland) · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptional profiling of antioxidant genes of Mycobacterium tuberculosis was performed by real-time RT-PCR during mouse lung infection and during adaptation to gradual oxygen depletion in vitro. M. tuberculosis genes involved in major detoxification pathways of oxidative stress were not up-regulated during chronic mouse lung infection, which is established in response to expression of host adaptive immunity. This result suggests that a major function of bacterial antioxidant enzymes is to protect from oxidants generated during the early, acute phase of infection. In vivo transcription profiles of bacterial antioxidant enzymes differed from those seen under adaptation to low oxygen in vitro, indicating differences between growth arrest in vivo and that induced by hypoxia in vitro.
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Registered trials
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