ArticleHormones and behavior2008
Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF).
Article in Hormones and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding.Psychopharmacology · 2026Article
- Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum.bioRxiv : the preprint server for biology · 2025Article
- Cellular and molecular signatures of motherhood in the adult and ageing rat brain.Open biology · 2023Article
- An IL-6 receptor antagonist attenuates postpartum anhedonia, but has no effect on anhedonia precipitated by subchronic stress in female rats.Psychopharmacology · 2019Article
- Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats.Psychopharmacology · 2019Article
- The influence of offspring, parity, and oxytocin on cognitive flexibility during the postpartum period.Hormones and behavior · 2017Article
- Separation increases passive stress-coping behaviors during forced swim and alters hippocampal dendritic morphology in California mice.PloS one · 2017Article
- Modeling menopause: The utility of rodents in translational behavioral endocrinology research.Maturitas · 2016Review
- The birth of new neurons in the maternal brain: Hormonal regulation and functional implications.Frontiers in neuroendocrinology · 2016Review
- Progestogens' effects and mechanisms for object recognition memory across the lifespan.Behavioural brain research · 2015Review
- Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?Hormones and behavior · 2015Article
- Hippocampal plasticity during the peripartum period: influence of sex steroids, stress and ageing.Journal of neuroendocrinology · 2014Review
- Estradiol and cognitive function: past, present and future.Hormones and behavior · 2014Review
- The maternal brain: an organ with peripartal plasticity.Neural plasticity · 2014Review
- Reproductive experience alters neural and behavioural responses to acute oestrogen receptor α activation.Journal of neuroendocrinology · 2013Article
- Review
- Age-related deficits in spatial memory and hippocampal spines in virgin, female Fischer 344 rats.Current gerontology and geriatrics research · 2011Article
- Parenting and plasticity.Trends in neurosciences · 2010Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess possible enduring effects of multiparity at least 3 months after the last litter was weaned. MP females performed significantly better than NP females on the non-spatial memory task, object recognition, and the spatial memory task, object placement. Anxiety as measured on the elevated plus maze did not differ between groups. Monoaminergic activity and levels were measured in prefrontal cortex, CA1 hippocampus, CA3 hippocampus, and olfactory bulb (OB). NP and MP females differed in monoamine concentrations in the OB only, with MP females having significantly greater concentrations of dopamine and metabolite DOPAC, norepinephrine and metabolite MHPG, and the serotonin metabolite 5-HIAA, as compared to NP females. These results indicate a long-term change in OB neurochemistry as a result of multiparity. Brain-derived neurotrophic factor (BDNF) was also measured in hippocampus (CA1, CA3, dentate gyrus) and septum. MP females had higher BDNF levels in both CA1 and septum; as these regions are implicated in memory performance, elevated BDNF may underlie the observed memory task differences. Thus, MP females (experiencing multiple bouts of pregnancy, birth, and pup rearing during the first year of life) displayed enhanced memory task performance but equal anxiety responses, as compared to NP females. These results are consistent with previous studies showing long-term changes in behavioral function in MP, as compared to NP, rats and suggest that alterations in monoamines and a neurotrophin, BDNF, may contribute to the observed behavioral changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.