ReviewDrugs2007
Recent advances in the pharmacological management of pain.
Review in Drugs, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
- Impact of Intraoperative Nefopam on Postoperative Pain, Opioid Use, and Recovery Quality with Parietal Pain Block in Single-Port Robotic Cholecystectomy: A Prospective Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Systemic antihyperalgesic effect of a novel conotoxin fromFrontiers in pain research (Lausanne, Switzerland) · 2024Article
- Effect of Nefopam on Dysesthesia, Postoperative Pain, and Satisfaction in Patients with Lumbar Spinal Stenosis Undergoing Spine Surgery: A Double-Blind, Randomized Study.Journal of clinical medicine · 2023Article
- Antioxidant Activity, Molecular Docking, Quantum Studies andFrontiers in pharmacology · 2021Article
- Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain.Drugs · 2019Review
- Dual FAAH and MAGL inhibition might play a key role in visceral pain.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Therapeutic Cannabis and Endocannabinoid Signaling System Modulator Use in Otolaryngology Patients.Laryngoscope investigative otolaryngology · 2018Review
- The cannabinoid system and pain.Neuropharmacology · 2017Review
- Allosteric modulation model of the mu opioid receptor by herkinorin, a potent not alkaloidal agonist.Journal of computer-aided molecular design · 2017Article
- Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents.Molecules (Basel, Switzerland) · 2016Article
- Antinociceptive effects of maprotiline in a rat model of peripheral neuropathic pain: possible involvement of opioid system.Iranian journal of basic medical sciences · 2015Article
- Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.British journal of pharmacology · 2015Article
- Rediscovery of nefopam for the treatment of neuropathic pain.The Korean journal of pain · 2014Review
- Neuropathic cancer pain: What we are dealing with? How to manage it?OncoTargets and therapy · 2014Review
- Intranasal administration of oxytocin: behavioral and clinical effects, a review.Neuroscience and biobehavioral reviews · 2013Article
- Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.British journal of pharmacology · 2012Article
- Novel targets for Spinal Cord Injury related neuropathic pain.Annals of neurosciences · 2011Review
- Article
- Analgesic efficacy of buprenorphine in the presence of high levels of SDF-1α/CXCL12 in the brain.Drug and alcohol dependence · 2011Article
- The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action.British journal of pharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is an unpleasant sensation that originates from ongoing or impending tissue damage. Management of different types of pain (acute, postoperative, inflammatory, neuropathic or cancer) is the most frequent issue encountered by clinicians and pharmacological therapy is the first line of approach for the treatment of pain. This review presents and discusses recent clinical advances regarding both the improvements in delivery of analgesic drugs and improvements in the design of analgesic molecules. The new modalities of administration of analgesics used in the clinic are reviewed, including skin patches, oral and mucosal sprays, transdermal delivery systems and intranasal administration. New insights are then presented on standard drugs used to relieve pain, such as opioids (including tramadol), NSAIDs including selective cyclo-oxygenase-2 inhibitors, paracetamol (acetaminophen), local anaesthetics and adjuvant analgesics such as antidepressants, anticonvulsants (gabapentin and pregabalin), cannabinoids, ketamine and others (e.g. nefopam). Although the understanding of pain mechanisms has improved significantly recently, much more is yet to be discovered and awaited. Broadening of our knowledge is needed to improve basic and clinical research in this field in order to better alleviate pain in millions of people.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.