ArticleLung2007
Decreased cytokine production in patients with nontuberculous mycobacterial lung disease.
Article in Lung, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Lymphocyte subsets and the increased risk for opportunistic infections in severe restrictive anorexia nervosa.Journal of eating disorders · 2025Article
- Growing from common ground: nontuberculous mycobacteria and bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Antibiotic Resistance toAntibiotics (Basel, Switzerland) · 2022Review
- T-cell deficiency and hyperinflammatory monocyte responses associate withFrontiers in immunology · 2022Article
- Personalised Medicine for Tuberculosis and Non-Tuberculous Mycobacterial Pulmonary Disease.Microorganisms · 2021Review
- Characteristics of Circulating CD4Journal of clinical medicine · 2020Article
- The Rise of Non-Tuberculosis Mycobacterial Lung Disease.Frontiers in immunology · 2020Review
- Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production.Open forum infectious diseases · 2019Article
- Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors.BMC infectious diseases · 2019Article
- Whole-Blood Gene Expression in Pulmonary Nontuberculous Mycobacterial Infection.American journal of respiratory cell and molecular biology · 2018Article
- Anomalies in T Cell Function Are Associated With Individuals at Risk ofFrontiers in immunology · 2018Article
- Changes in cholesterol level correlate with the course of pulmonary nontuberculous mycobacterial disease.Journal of thoracic disease · 2016Article
- Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report.Annals of the American Thoracic Society · 2016Article
- '"Why me, why now?" Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection.BMC medicine · 2016Review
- Differential Impairment of Interferon-Case reports in immunology · 2016Article
- Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management.PLoS neglected tropical diseases · 2014Article
- Changes in serum immunomolecules during antibiotic therapy for Mycobacterium avium complex lung disease.Clinical and experimental immunology · 2014Observational
- Importance of reciprocal balance of T cell immunity in Mycobacterium abscessus complex lung disease.PloS one · 2014Article
- Bedfellows: mycobacteria and rheumatoid arthritis in the era of biologic therapy.Nature reviews. Rheumatology · 2013Review
- Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium.American journal of respiratory and critical care medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nontuberculous mycobacteria (NTM) are intracellular pathogens that elicit a specific T-cell response characterized by the production of proinflammatory cytokines, including interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-12. However, little information exists regarding the levels of specific cytokines in patients with NTM lung disease. Therefore, we compared cytokine production in peripheral blood mononuclear cells (PBMCs) from patients with NTM lung disease with that in PBMCs from healthy controls. Pro- and anti-inflammatory cytokine production was measured by enzyme-linked immunosorbent assay in the PBMCs of 29 patients with NTM lung disease and 15 healthy controls. Phytohemagglutinin (PHA)-induced IFN-gamma production and lipopolysaccharide (LPS)-induced production of TNF-alpha and IL-12p40 were significantly lower in the PBMCs of patients with NTM lung disease than in those of the healthy controls. The production of these cytokines did not differ significantly between patients infected with Mycobacterium avium complex (MAC) and those infected with Mycobacterium abscessus; however, IL-10 production was lower in patients infected with M. abscessus than in those infected with MAC. Decreased IFN-gamma, TNF-alpha, and IL-12 production may be associated with host susceptibility to the development of MAC and M. abscessus lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.