Evidence map›Paper›PMID 17925998›Full record

ArticleJournal of human genetics2007

HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.

Laurent Jacq, Vitor Hugo Teixeira, Sophie Garnier, Laëtitia Michou, Philippe Dieudé, Dominique Rocha, Céline Pierlot, Isabelle Lemaire, Patrick Quillet, Pascal Hilliquin and 3 more

Open access · bronzeAbstract read
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In one paragraph

Article in Journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Laurent JacqGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France. Laurent@polyarthrite.net.
Vitor Hugo TeixeiraGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Sophie GarnierGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Laëtitia MichouGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Philippe DieudéGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Dominique RochaGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Céline PierlotGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Isabelle LemaireGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Patrick QuilletGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Pascal HilliquinHôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
Hamdi MbarekGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Elisabeth Petit-TeixeiraGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
François CornélisGenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Genopole (France) · FRUniversité Paris Cité · FRCentre Hospitalier Sud Francilien · FRAssistance Publique – Hôpitaux de Paris · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population.

Indexed as

Polymorphism, Single NucleotideAdultArthritis, RheumatoidChaperonin 60ChaperoninsFamily HealthFemaleFranceGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumMaleMicrotubule-Associated ProteinsChaperonin 60ChaperoninsHSPD1 protein, humanMicrotubule-Associated ProteinsMitochondrial Proteins

Identifiers

PMID17925998
OpenAlexW2150268691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.