ReviewMolecular psychiatry2008
The myelin-pathogenesis puzzle in schizophrenia: a literature review.
Review in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Brain Inflammatory Marker Abnormalities in Major Psychiatric Diseases: a Systematic Review of Postmortem Brain Studies.Molecular neurobiology · 2023Pooled it
- Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.Molecular psychiatry · 2016Pooled it
- Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.Molecular psychiatry · 2025Review
- Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice.Nature communications · 2023Article
- Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.Anatomical science international · 2023Review
- Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia.Journal of personalized medicine · 2022Article
- Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.Schizophrenia research. Cognition · 2022Review
- Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes.Translational psychiatry · 2021Article
- Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis.Molecular psychiatry · 2021Article
- Drug-naive patients with schizophrenia have metabolic disorders that are not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes.International journal of clinical and experimental pathology · 2018Article
- Comparison of Reprogramming Methods for Generation of Induced-Oligodendrocyte Precursor Cells.Biomolecules & therapeutics · 2017Article
- High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy.Frontiers in pharmacology · 2017Article
- Increased Cx32 expression in spinal cord TrkB oligodendrocytes following peripheral axon injury.Neuroscience letters · 2016Article
- Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.Molecular psychiatry · 2015Article
- Association between upstream purine complexes of human caveolin-1 gene and schizophrenia in qazvin province of iran.Iranian Red Crescent medical journal · 2014Article
- Distribution and phenotype of TrkB oligodendrocyte lineage cells in the adult rat spinal cord.Brain research · 2014Article
- White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis.Schizophrenia research · 2014Article
- Stereological assessment of the dorsal anterior cingulate cortex in schizophrenia: absence of changes in neuronal and glial densities.Neuropathology and applied neurobiology · 2013Article
- Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.American journal of human genetics · 2013Article
- White matter integrity, language, and childhood onset schizophrenia.Schizophrenia research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a serious and disabling mental disorder with symptoms such as auditory hallucinations, disordered thinking and delusions, avolition, anhedonia, blunted affect and apathy. In this review article we seek to present the current scientific findings from linkage studies and susceptible genes and the pathophysiology of white matter in schizophrenia. The article has been reviewed in two parts. The first part deals with the linkage studies and susceptible genes in schizophrenia in order to have a clear-cut picture of the involvement of chromosomes and their genes in schizophrenia. The genetic linkage results seem to be replicated in some cases but in others are not. From these results, we cannot draw a fine map to a single locus or gene, leading to the conclusion that schizophrenia is not caused by a single factor/gene. In the second part of the article we present the oligodendrocyte-related genes that are associated with schizophrenia, as we hypothesize a potential role of oligodendrocyte-related genes in the pathology of the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.