ReviewProgress in brain research2007
Modeling the mammalian locomotor CPG: insights from mistakes and perturbations.
Review in Progress in brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 127 citations in OpenAlex.
- Motor modules in robot-aided walking.Journal of neuroengineering and rehabilitation · 2012Trial
- Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Article
- Spinal control of locomotion before and after spinal cord injury.Experimental neurology · 2023Article
- Rare phenomena of central rhythm and pattern generation in a case of complete spinal cord injury.Nature communications · 2023Article
- Spinal control of locomotion before and after spinal cord injury.bioRxiv : the preprint server for biology · 2023Article
- Action-rule-based cognitive control enables efficient execution of stimulus-response conflict tasks: a model validation of Simon task performance.Frontiers in human neuroscience · 2023Article
- Left-Right Locomotor Coordination in Human Neonates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling.International journal of molecular sciences · 2022Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Locomotor Pattern and Force Generation Modulated by Ionic Channels: A Computational Study of Spinal Networks Underlying Locomotion.Frontiers in computational neuroscience · 2022Article
- Achieving natural behavior in a robot using neurally inspired hierarchical perceptual control.iScience · 2021Article
- Common and distinct muscle synergies during level and slope locomotion in the cat.Journal of neurophysiology · 2021Article
- Computational Modeling of Spinal Locomotor Circuitry in the Age of Molecular Genetics.International journal of molecular sciences · 2021Review
- Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Neuronal Actions of Transspinal Stimulation on Locomotor Networks and Reflex Excitability During Walking in Humans With and Without Spinal Cord Injury.Frontiers in human neuroscience · 2021Article
- A modeling study of spinal motoneuron recruitment regulated by ionic channels during fictive locomotion.Journal of computational neuroscience · 2020Article
- Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.Frontiers in neural circuits · 2020Article
- Flexor and Extensor Ankle Afferents Broadly Innervate Locomotor Spinal Shox2 Neurons and Induce Similar Effects in Neonatal Mice.Frontiers in cellular neuroscience · 2019Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-center rhythm generator (RG) and pattern formation (PF) networks is reviewed. The model consists of interacting populations of interneurons and motoneurons described in the Hodgkin-Huxley style. Locomotor rhythm generation is based on a combination of intrinsic (persistent sodium current dependent) properties of excitatory RG neurons and reciprocal inhibition between the two half-centers comprising the RG. The two-level architecture of the CPG was suggested from an analysis of deletions (spontaneous omissions of activity) and the effects of afferent stimulation on the locomotor pattern and rhythm observed during fictive locomotion in the cat. The RG controls the activity of the PF network that in turn defines the rhythmic pattern of motoneuron activity. The model produces realistic firing patterns of two antagonist motoneuron populations and generates locomotor oscillations encompassing the range of cycle periods and phase durations observed during cat locomotion. A number of features of the real CPG operation can be reproduced with separate RG and PF networks, which would be difficult if not impossible to demonstrate with a classical single-level CPG. The two-level architecture allows the CPG to maintain the phase of locomotor oscillations and cycle timing during deletions and during sensory stimulation. The model provides a basis for functional identification of spinal interneurons involved in generation and control of the locomotor pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.