ArticleDevelopmental cell2007
Putting the brakes on cytokinesis with alpha-actinin.
Article in Developmental cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Micropipette Aspiration of Oocytes to Assess Cortical Tension.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Pharmacological activation of myosin II paralogs to correct cell mechanics defects.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy.Biology of reproduction · 2013Article
- Molecular mechanics of the alpha-actinin rod domain: bending, torsional, and extensional behavior.PLoS computational biology · 2009Article
- The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.Molecular cancer · 2008Article
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Authors and funding
2 authors.
Funding
Abstract
Although signal transduction pathways provide spatiotemporal control of cytokinesis, additional regulation likely occurs through complex cytoskeletal network interactions. In this issue of Developmental Cell, Mukhina et al. (2007) show that myosin-II modulates the cortical lifetime of the actin crosslinker alpha-actinin, which in turn tunes actin filament dynamics, thereby controlling furrow ingression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.