ArticleAnnals of general psychiatry2007
Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder.
Article in Annals of general psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry.European archives of psychiatry and clinical neuroscience · 2012Pooled it
- Is anticonvulsant treatment of mania a class effect? Data from randomized clinical trials.CNS neuroscience & therapeutics · 2011Pooled it
- The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals.Pharmaceutics · 2025Review
- Challenges in the development of treatment guidelines for bipolar disorder.Frontiers in psychiatry · 2025Article
- Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy.Journal of personalized medicine · 2021Article
- The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines.The international journal of neuropsychopharmacology · 2017Review
- Pharmaco-utilisation and related costs of drugs used to treat schizophrenia and bipolar disorder in Italy: the IBIS study.BMC psychiatry · 2014Observational
- Refractoriness in bipolar disorder: definitions and evidence-based treatment.CNS neuroscience & therapeutics · 2012Review
- Pharmacogenetics of antidepressant drugs: current clinical practice and future directions.Pharmacogenomics · 2012Review
- Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?Annals of general psychiatry · 2011Article
- Pharmaceutical treatment of acute bipolar depression.F1000 medicine reports · 2010Article
- Role of extended release quetiapine in the management of bipolar disorders.Neuropsychiatric disease and treatment · 2010Article
- Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis.Annals of general psychiatry · 2009Article
- Review
- Comorbid mood, psychosis, and marijuana abuse disorders: a theoretical review.Journal of addictive diseases · 2009Review
- Medication use in adolescents treated in a French psychiatric setting for acute manic or mixed episode.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2009Article
- Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review.Annals of general psychiatry · 2009Article
- Mixed states vs. pure mania in the French sample of the EMBLEM study: results at baseline and 24 months--European mania in bipolar longitudinal evaluation of medication.BMC psychiatry · 2009Article
- Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats.Neurochemical research · 2008Article
- Three cases of reversible agranulocytosis after treatment with lamotrigine.Psychiatry investigation · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment.
methodsThis article summarizes the current status of our knowledge and practice of its treatment.
resultsIt is widely accepted that lithium is moderately useful during all phases of bipolar illness and it might possess a specific effectiveness on suicidal prevention. Both first and second generation antipsychotics are widely used and the FDA has approved olanzapine, risperidone, quetiapine, ziprasidone and aripiprazole for the treatment of acute mania. These could also be useful in the treatment of bipolar depression, but only limited data exists so far to support the use of quetiapine monotherapy or the olanzapine-fluoxetine combination. Some, but not all, anticonvulsants possess a broad spectrum of effectiveness, including mixed dysphoric and rapid-cycling forms. Lamotrigine may be effective in the treatment of depression but not mania. Antidepressant use is controversial. Guidelines suggest their cautious use in combination with an antimanic agent, because they are supposed to induce switching to mania or hypomania, mixed episodes and rapid cycling.
conclusionThe first-line psychosocial intervention in BD is psychoeducation, followed by cognitive-behavioral therapy. Other treatment options include Electroconvulsive therapy and transcranial magnetic stimulation. There is a gap between the evidence base, which comes mostly from monotherapy trials, and clinical practice, where complex treatment regimens are the rule.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.