ArticleBrain pathology (Zurich, Switzerland)2008
Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain.
Article in Brain pathology (Zurich, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- A bibliometric study on clinical research in neonatal encephalopathy.Frontiers in pediatrics · 2024Review
- Motor function and white matter connectivity in children cooled for neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Wavelet pressure reactivity index: a validation study.The Journal of physiology · 2018Article
- Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2017Article
- Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.Pediatric research · 2016Article
- In vivo correlates of thermoregulatory defense in humans: Temporal course of sub-cortical and cortical responses assessed with fMRI.Human brain mapping · 2016Article
- Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Effects of hypothermia combined with neural stem cell transplantation on recovery of neurological function in rats with spinal cord injury.Molecular medicine reports · 2015Article
- Breathing and temperature control disrupted by morphine and stabilized by clonidine in neonatal rats.Respiratory physiology & neurobiology · 2014Article
- Bench to cribside: the path for developing a neuroprotectant.Translational stroke research · 2013Review
- Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study.BMC pediatrics · 2012Article
- Electrophysiological functional recovery in a rat model of spinal cord hemisection injury following bone marrow-derived mesenchymal stem cell transplantation under hypothermia.Neural regeneration research · 2012Article
- Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs.Pediatric research · 2011Article
- Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.PloS one · 2010Article
- Bench-to-bedside review: Hypothermia in traumatic brain injury.Critical care (London, England) · 2010Review
- Hypoxic-ischemic encephalopathy in the term infant.Clinics in perinatology · 2009Review
- Mild hypoxic-ischemic injury in the neonatal rat brain: longitudinal evaluation of white matter using diffusion tensor MR imaging.AJNR. American journal of neuroradiology · 2009Article
- Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia.Journal of neurotrauma · 2009Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Hypothermia (HT) by whole body (WBC) or selective head cooling (SHC) reduces hypoxic-ischemic (HI) brain injury; however, whether prolonged hypothermia and/or anesthesia disrupts immature brain development, eg, increases apoptosis, is unknown. Anesthesia increases apoptosis in immature animals. We investigated whether neuroprotective hypothermia and anesthesia disrupts normal brain development. Thirty-eight pigs <24 h old were randomized between five groups and were killed after 72 h: eighteen received a global hypoxic-ischemic insult under anesthesia, eight subsequently cooled by SHC with WBC to T(rectal) 34.5 degrees C for 24 h, followed by 48 h normothermia (NT) at T(rectal) 39.0 degrees C, while 10 remained normothermic. Sixteen underwent anesthetized sham hypoxic-ischemic, six then following normothermia and 10 following hypothermia protocols. There were four normothermic controls. The hypothermia groups demonstrated significant brain hypothermia. In the hypoxic-ischemic groups this conferred approximately 60% neuroprotection reducing histological injury scores in all brain areas. Immunohistochemical/histochemical analyses of neuronal, glial, endothelial, axonal, transcriptional apoptotic markers in areas devoid of histological lesions revealed no hypothermia/normothermia group and differences whether exposed to hypoxic-ischemic or not. Neither 36-h anesthesia nor 24-h hypothermia produced adverse effects at 4-day survival on a panel of brain maturation/neural death markers in newborn pigs. Longer survival studies are necessary to verify the safety of hypothermia in the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.