ArticleAmerican journal of human genetics2007
Genome partitioning of genetic variation for height from 11,214 sibling pairs.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Meta-analysis of genome-wide association from genomic prediction models.Animal genetics · 2016Pooled it
- Evidence of inbreeding depression on human height.PLoS genetics · 2012Pooled it
- The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth.Human genetics · 2015Trial
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- Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.Human brain mapping · 2024Article
- Heritability Estimation Approaches Utilizing Genome-Wide Data.Current protocols · 2023Review
- Analysis of historical selection in winter wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- UK IBD Twin Registry: Concordance and Environmental Risk Factors of Twins with IBD.Digestive diseases and sciences · 2022Article
- Average semivariance directly yields accurate estimates of the genomic variance in complex trait analyses.G3 (Bethesda, Md.) · 2022Article
- Genomic architecture of phenotypic extremes in a wild cervid.BMC genomics · 2022Article
- Comparing empirical kinship derived heritability for imaging genetics traits in the UK biobank and human connectome project.NeuroImage · 2021Article
- Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop.Circulation. Cardiovascular imaging · 2021Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- Human Connectome Project: heritability of brain volumes in young healthy adults.Experimental brain research · 2021Article
- Correlation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impaction.Journal of maxillofacial and oral surgery · 2021Article
- Variation in Genetic Relatedness Is Determined by the Aggregate Recombination Process.Genetics · 2020Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Height has been used for more than a century as a model by which to understand quantitative genetic variation in humans. We report that the entire genome appears to contribute to its additive genetic variance. We used genotypes and phenotypes of 11,214 sibling pairs from three countries to partition additive genetic variance across the genome. Using genome scans to estimate the proportion of the genomes of each chromosome from siblings that were identical by descent, we estimated the heritability of height contributed by each of the 22 autosomes and the X chromosome. We show that additive genetic variance is spread across multiple chromosomes and that at least six chromosomes (i.e., 3, 4, 8, 15, 17, and 18) are responsible for the observed variation. Indeed, the data are not inconsistent with a uniform spread of trait loci throughout the genome. Our estimate of the variance explained by a chromosome is correlated with the number of times suggestive or significant linkage with height has been reported for that chromosome. Variance due to dominance was not significant but was difficult to assess because of the high sampling correlation between additive and dominance components. Results were consistent with the absence of any large between-chromosome epistatic effects. Notwithstanding the proposed architecture of complex traits that involves widespread gene-gene and gene-environment interactions, our results suggest that variation in height in humans can be explained by many loci distributed over all autosomes, with an additive mode of gene action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.