ArticleAmerican journal of human genetics2007
The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding.Translational psychiatry · 2014Article
- Article
- Genome-wide searches for bipolar disorder genes.Current psychiatry reports · 2011Article
- Genome-wide association study of the child behavior checklist dysregulation profile.Journal of the American Academy of Child and Adolescent Psychiatry · 2011Article
- Gene expression and genetic variation data implicate PCLO in bipolar disorder.Biological psychiatry · 2011Article
- Article
- Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Role for protein-protein interaction databases in human genetics.Expert review of proteomics · 2009Review
- The genetics of bipolar disorder.Neuroscience · 2009Review
- Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.Nature reviews. Genetics · 2008Review
- CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2008Article
- Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.American journal of human genetics · 2008Article
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Authors and funding
30 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder (BPAD), using a large linkage data set (52 families of European descent; 448 participants and 259 affected individuals). Our results provide the strongest interaction evidence between BPAD genes on chromosomes 2q22-q24 and 6q23-q24, which was observed symmetrically in both directions (nonparametric LOD [NPL] scores of 7.55 on 2q and 7.63 on 6q; P<.0001 and P=.0001, respectively, after a genomewide permutation procedure). The second-best BPAD interaction evidence was observed between chromosomes 2q22-q24 and 15q26. Here, we also observed a symmetrical interaction (NPL scores of 6.26 on 2q and 4.59 on 15q; P=.0057 and .0022, respectively). We covered the implicated regions by genotyping additional marker sets and performed a detailed interaction linkage analysis, which narrowed the susceptibility intervals. Although the heterogeneity analysis produced less impressive results (highest NPL score of 3.32) and a less consistent picture, we achieved evidence of locus heterogeneity at chromosomes 2q, 6p, 11p, 13q, and 22q, which was supported by adjacent markers within each region and by previously reported BPAD linkage findings. Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies.
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