ArticleCurrent microbiology2007
Comparison of mecA polymerase chain reaction with phenotypic methods for the detection of methicillin-resistant Staphylococcus aureus.
Article in Current microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
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- Antimicrobial resistance profiles of salmonella spp. and escherichia coli isolated from fresh nile tilapia (oreochromis niloticus) fish marketed for human consumption.BMC microbiology · 2023Article
- ARGs Detection inMicroorganisms · 2023Article
- Occurrence and Molecular Characterization of Multidrug-Resistant Vegetable-BorneAntibiotics (Basel, Switzerland) · 2022Article
- A survey of prevalence and phenotypic and genotypic assessment of antibiotic resistance in Staphylococcus aureus bacteria isolated from ready-to-eat food samples collected from Tehran Province, Iran.Tropical medicine and health · 2021Article
- Comparison of PCR and phenotypic methods for the detection of methicillin resistantIranian journal of microbiology · 2021Article
- Phenotypic and Genotypic Assessment of Antibiotic Resistance ofInfection and drug resistance · 2020Article
- Antimicrobial Susceptibility Testing and Phenotypic Detection of MRSA Isolated from Diabetic Foot Infection.International journal of general medicine · 2020Article
- Phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistantAntimicrobial resistance and infection control · 2019Article
- Biofilm-Forming ClinicalFrontiers in microbiology · 2017Article
- Hemoculture and Direct Sputum Detection of mecA-Mediated Methicillin-Resistant Staphylococcus aureus by Loop-Mediated Isothermal Amplification in Combination With a Lateral-Flow Dipstick.Journal of clinical laboratory analysis · 2016Article
- Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.MicrobiologyOpen · 2016Article
- Genotyping of methicillin-resistant Staphylococcus aureus in the Sultan Qaboos University Hospital, Oman reveals the dominance of Panton-Valentine leucocidin-negative ST6-IV/t304 clone.New microbes and new infections · 2014Article
- Antimicrobial resistance and characterisation of staphylococci isolated from healthy Labrador retrievers in the United Kingdom.BMC veterinary research · 2014Article
- Impairments of mecA gene detection in bovine Staphylococcus spp.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- The comparison of Staphylococcus aureus types 5 and 8 with respect to methicillin resistance in patients admitted to Al-Zahra Hospital by PCR.Advanced biomedical research · 2013Article
- Antibiotic resistance genes & susceptibility patterns in staphylococci.The Indian journal of medical research · 2012Article
- Comparison of real-time PCR with disk diffusion, agar screen and E-test methods for detection of methicillin-resistant Staphylococcus aureus.Current microbiology · 2010Article
- Evaluation of different methods for detecting methicillin resistance in Staphylococcus aureus isolates in a university hospital located in the Northeast of Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, several conventional methods to detect methicillin-resistant Staphylococcus aureus (MRSA) were compared with polymerase chain reaction (PCR) detection of mecA gene-positive isolates. Cefoxitin E-test was also evaluated as a possible phenotypic method of MRSA detection. Oxacillin agar screen and PBP2' latex agglutination methods were found to be more sensitive than oxacillin and cefoxitin disk-diffusion methods. Cefoxitin disk diffusion was found to be the most specific. A combination of oxacillin agar screening with cefoxitin disk diffusion, or oxacillin disk diffusion with PBP2', improved sensitivity and specificity. Cefoxitin E-test with the current break points had low sensitivity and specificity (33.3% and 75%, respectively) for the detection of MRSA. However, changing the break points to <or= 4 microg/ml and to >or= 6 microg/ml for sensitive and resistant, respectively, greatly improved both. Changing the 30-microg cefoxitin disk-diffusion break points to <or= 21 mm for resistant slightly improved sensitivity but had no effect on specificity. It was therefore concluded that the use of more than one screening method is necessary to detect all MRSA isolates in clinical settings.
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