Trial reportJournal of endocrinological investigation2007
Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals.
Trial report in Journal of endocrinological investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals.American journal of physiology. Endocrinology and metabolism · 2026Trial
- Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise.Lipids in health and disease · 2011Trial
- Visceral fat endocannabinoid overproduction is associated with insulin resistance and tissue dysfunction in mice and humans.Diabetologia · 2026Article
- Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway.International journal of medical sciences · 2026Article
- Interplays of Dietary Fat with BMI andFood science & nutrition · 2024Article
- Maternal high-fat diet up-regulates type-1 cannabinoid receptor with estrogen signaling changes in a sex- and depot- specific manner in white adipose tissue of adult rat offspring.European journal of nutrition · 2021Article
- Endocannabinoids and Stroke Prevention: Review of Clinical Studies.Cannabis and cannabinoid research · 2020Review
- Endocannabinoid System in Hepatic Glucose Metabolism, Fatty Liver Disease, and Cirrhosis.International journal of molecular sciences · 2019Review
- Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.Nutrition & diabetes · 2018Article
- Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.Endocrine · 2017Article
- Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity.Journal of physiology and biochemistry · 2016Article
- Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.Journal of medicinal food · 2014Article
- The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes.Lipids in health and disease · 2014Article
- Fatty Acid modulation of the endocannabinoid system and the effect on food intake and metabolism.International journal of endocrinology · 2013Article
- Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA).Genome medicine · 2012Article
- Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.Reviews in endocrine & metabolic disorders · 2011Review
- The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans.Lipids in health and disease · 2011Article
- Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.Diabetologia · 2010Article
- Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.Lipids in health and disease · 2010Article
- Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.Pharmacogenomics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human obesity has been associated with a dysregulation of the peripheral and adipose tissue (AT) endocannabinoid system (ES). The aim of this study was to elucidate the acute in vivo effects of insulin on gene expression of the cannabinoid type 1 (CB-1) and type 2 (CB-2) receptors, as well as of the fatty acid amide hydrolase (FAAH) in the sc abdominal adipose tissue (SCAAT). Nine lean (L) and 9 obese (OB), but otherwise healthy males were studied in the fasting state and during a euglycemic hyperinsulinemic clamp (40 mU/m2 * min(-1)). SCAAT biopsies were obtained at baseline and after 270 min of i.v. maintained hyperinsulinemia. The basal SCAAT gene expression pattern revealed an upregulation of the FAAH in the OB (p=0.03 vs L), whereas similar CB-1 and CB-2 mRNA levels were seen. Following hyperinsulinemia, the FAAH mRNA levels significantly increased approximately 2-fold in the L (p=0.01 vs baseline) but not in the OB. In contrast, insulin failed to significantly change both the adipose CB-1 and CB-2 gene expression. Finally, the FAAH gene expression positively correlated with the fasting serum insulin concentration (r 0.66; p=0.01), whereas an inverse association with the whole-body glucose disposal (r -0.58; p<0.05) was seen. Taken together, these first time observations demonstrate that the ES-related genes in the SCAAT differentially respond to hyperinsulinemia in lean/insulin-sensitive and in obese/insulin-resistant individuals. We suggest that insulin may play a key role in the obesity-linked dysregulation of the adipose ES at the gene level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.