ArticleMolecular and cellular biology2007
dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- L(3)mbt and the LINT complex safeguard cellular identity in theDevelopment (Cambridge, England) · 2018Article
- Temporal remodeling of the cell cycle accompanies differentiation in the Drosophila germline.Developmental biology · 2017Article
- E2F function in muscle growth is necessary and sufficient for viability in Drosophila.Nature communications · 2016Article
- Loss of dE2F compromises mitochondrial function.Developmental cell · 2013Article
- Atypical E2F repressors and activators coordinate placental development.Developmental cell · 2012Article
- Pumilio facilitates miRNA regulation of the E2F3 oncogene.Genes & development · 2012Article
- S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.PLoS genetics · 2012Article
- Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades.PLoS genetics · 2012Article
- DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells.Development (Cambridge, England) · 2011Article
- A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.The Journal of cell biology · 2010Article
- Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster.BMC genomics · 2010Article
- Mutation of the DEAD-box helicase belle downregulates the cyclin-dependent kinase inhibitor Dacapo.Cell cycle (Georgetown, Tex.) · 2010Article
- Emerging roles of E2Fs in cancer: an exit from cell cycle control.Nature reviews. Cancer · 2009Review
- Article
- Context-dependent requirement for dE2F during oncogenic proliferation.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In Drosophila melanogaster, the loss of activator de2f1 leads to a severe reduction in cell proliferation and repression of E2F targets. To date, the only known way to rescue the proliferation block in de2f1 mutants was through the inactivation of dE2F2. This suggests that dE2F2 provides a major contribution to the de2f1 mutant phenotype. Here, we report that in mosaic animals, in addition to de2f2, the loss of a DEAD box protein Belle (Bel) also rescues proliferation of de2f1 mutant cells. Surprisingly, the rescue occurs in a dE2F2-independent manner since the loss of Bel does not relieve dE2F2-mediated repression. In the eye disc, bel mutant cells fail to undergo a G1 arrest in the morphogenetic furrow, delay photoreceptor recruitment and differentiation, and show a reduction of the transcription factor Ci155. The down-regulation of Ci155 is important since it is sufficient to partially rescue proliferation of de2f1 mutant cells. Thus, mutation of bel relieves the dE2F2-mediated cell cycle arrest in de2f1 mutant cells through a novel Ci155-dependent mechanism without functional inactivation of the dE2F2 repressor.
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