ArticleThe Journal of cell biology2007
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025Review
- The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex.Journal of cellular and molecular medicine · 2025Review
- PALS1-dependent modulations of mRNA profiles in MDCK II cells grown in non-confluent monolayers and three-dimensional cysts.BMC genomic data · 2024Article
- Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.iScience · 2022Article
- Impact of Pals1 on Expression and Localization of Transporters Belonging to the Solute Carrier Family.Frontiers in molecular biosciences · 2022Article
- Scaffold protein Lin7 family in membrane skeletal protein complex in mouse seminiferous tubules.Histochemistry and cell biology · 2019Article
- Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.Biochemistry · 2018Article
- Rosiglitazone affects lumen formation in MDCKII cell through regulating apico-basal polarity.American journal of translational research · 2018Article
- Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system.Histochemistry and cell biology · 2017Article
- Cross talk between the Crumbs complex and Hippo signaling in renal epithelial cells.Pflugers Archiv : European journal of physiology · 2017Review
- Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.Journal of the American Society of Nephrology : JASN · 2017Article
- Outside the mainstream: novel collecting duct proteins regulating water balance.American journal of physiology. Renal physiology · 2016Review
- Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo.Scientific reports · 2015Article
- The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.Nature · 2015Article
- Crumbs3 is essential for proper epithelial development and viability.Molecular and cellular biology · 2014Article
- Cell polarity and cystic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.The Journal of biological chemistry · 2012Article
- Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.Human molecular genetics · 2012Article
- Apicobasal polarity in the kidney.Experimental cell research · 2012Review
- Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney development and physiology require polarization of epithelia that line renal tubules. Genetic studies show that polarization of invertebrate epithelia requires the crumbs, partition-defective-3, and discs large complexes. These evolutionarily conserved protein complexes occur in mammalian kidney; however, their role in renal development remains poorly defined. Here, we find that mice lacking the small PDZ protein mammalian LIN-7c (MALS-3) have hypomorphic, cystic, and fibrotic kidneys. Proteomic analysis defines MALS-3 as the only known core component of both the crumbs and discs large cell polarity complexes. MALS-3 mediates stable assembly of the crumbs tight junction complex and the discs large basolateral complex, and these complexes are disrupted in renal epithelia from MALS-3 knockout mice. Interestingly, MALS-3 controls apico-basal polarity preferentially in epithelia derived from metanephric mesenchyme, and defects in kidney architecture owe solely to MALS expression in these epithelia. These studies demonstrate that defects in epithelial cell polarization can cause cystic and fibrotic renal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.