ArticleThe Journal of experimental medicine2007
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 117 citations in OpenAlex.
- CD127International journal of molecular sciences · 2026Article
- Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development.Frontiers in immunology · 2024Article
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- IL-15 Generates IFN-γ-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell Differentiation.International journal of biological sciences · 2019Article
- Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific.Nature immunology · 2018Article
- Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection.Virology journal · 2017Article
- Dendritic cell targeted vaccines: Recent progresses and challenges.Human vaccines & immunotherapeutics · 2016Article
- High expression of CD11c indicates favorable prognosis in patients with gastric cancer.World journal of gastroenterology · 2015Article
- Expansion of an atypical NK cell subset in mouse models of systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.International journal of clinical and experimental medicine · 2015Article
- Tumoricidal activity of human dendritic cells.Trends in immunology · 2014Review
- Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases.Journal of immunology research · 2014Article
- Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells.Frontiers in immunology · 2013Review
- Review
- Dendritic cell tumor killing activity and its potential applications in cancer immunotherapy.Critical reviews in immunology · 2013Review
- Interleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential.PloS one · 2012Article
- Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.PloS one · 2012Article
- Tolerogen-induced interferon-producing killer dendritic cells (IKDCs) protect against EAE.Journal of autoimmunity · 2011Article
- Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon-producing killer dendritic cells (IKDCs) have been described as possessing the lytic potential of NK cells and the antigen-presenting capacity of dendritic cells (DCs). In this study, we examine the lytic function and antigen-presenting capacity of mouse spleen IKDCs, including those found in DC preparations. IKDCs efficiently killed NK cell targets, without requiring additional activation stimuli. However, in our hands, when exposed to protein antigen or to MHC class II peptide, IKDCs induced little or no T cell proliferation relative to conventional DCs or plasmacytoid DCs, either before or after activation with CpG, or in several disease models. Certain developmental features indicated that IKDCs resembled NK cells more than DCs. IKDCs, like NK cells, did not express the transcription factor PU.1 and were absent from recombinase activating gene-2-null, common gamma-chain-null (Rag2(-/-)Il2rg(-/-)) mice. When cultured with IL-15 and -18, IKDCs proliferated extensively, like NK cells. Under these conditions, a proportion of expanded IKDCs and NK cells expressed high levels of surface MHC class II. However, even such MHC class II(+) IKDCs and NK cells induced poor T cell proliferative responses compared with DCs. Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.