ArticleThe Journal of experimental medicine2007
A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
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- JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy.Postgraduate medicine · 2021Review
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- Mesenchymal Stem Cells in COVID-19: A Journey from Bench to Bedside.Laboratory medicine · 2021Review
- Regen med therapeutic opportunities for fighting COVID-19.Stem cells translational medicine · 2021Article
- Health practitioners should caution about misinformation and association of adverse effects of electronic cigarette use and COVID-19.Preventive medicine reports · 2020Article
- Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications.Life sciences · 2020Review
- SARS-CoV-2 infection and stem cells: Interaction and intervention.Stem cell research · 2020Review
- COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice.Human genomics · 2020Review
- Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.Frontiers in immunology · 2020Review
- Consecutive Hypoxia Decreases Expression ofFrontiers in cell and developmental biology · 2020Article
- Human lung ex vivo infection models.Cell and tissue research · 2017Review
- Positive selection of the TRIM family regulatory region in primate genomes.Proceedings. Biological sciences · 2016Article
- NMR evidence for oligosaccharide release from the dendritic-cell specific intercellular adhesion molecule 3-grabbing non-integrin-related (CLEC4M) carbohydrate recognition domain at low pH.The FEBS journal · 2014Article
- Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds.Nature nanotechnology · 2013Article
- Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments.The Journal of biological chemistry · 2013Article
- Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation.The Journal of infectious diseases · 2013Article
- Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus.American journal of respiratory cell and molecular biology · 2013Article
- Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.Journal of virology · 2013Article
- Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract.Current opinion in virology · 2012Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Identification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS(+) cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.