ReviewThe British journal of nutrition2007
Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract.
Review in The British journal of nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review).Molecular medicine reports · 2025Review
- Science-based evidence on pathways and effects of human exposure to micro- and nanoplastics.Arhiv za higijenu rada i toksikologiju · 2024Review
- Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts.iScience · 2023Review
- A review on enhanced microplastics derived from biomedical waste during the COVID-19 pandemic with its toxicity, health risks, and biomarkers.Environmental research · 2023Review
- To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity.Exposure and health · 2023Review
- Adverse health effects of emerging contaminants on inflammatory bowel disease.Frontiers in public health · 2023Review
- Diets for inflammatory bowel disease: What do we know so far?European journal of clinical nutrition · 2022Review
- Crohn's Disease: Is the Cold Chain Hypothesis Still Hot?Journal of Crohn's & colitis · 2021Review
- Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT116.PloS one · 2021Article
- Effects of microplastics and nanoplastics on marine environment and human health.Environmental science and pollution research international · 2020Review
- Microplastics in waters and soils: Occurrence, analytical methods and ecotoxicological effects.Ecotoxicology and environmental safety · 2020Review
- Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles.Scientific reports · 2019Article
- Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing.Particle and fibre toxicology · 2017Article
- Review
- Presence of microplastics and nanoplastics in food, with particular focus on seafood.EFSA journal. European Food Safety Authority · 2016Article
- An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.Nature nanotechnology · 2015Article
- Engineered nanomaterials in food: implications for food safety and consumer health.International journal of environmental research and public health · 2014Review
- Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- The gut wall provides an effective barrier against nanoparticle uptake.Beilstein journal of nanotechnology · 2014Article
- Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dietary microparticles are non-biological bacterial-sized particles of the gastrointestinal lumen that occur due to endogenous formation (calcium phosphate) or following oral exposure (exogenous microparticle). In the UK, about 40 mg (10(12)) of exogenous microparticles are ingested per person per day, through exposure to food additives, pharmaceutical/supplement excipients or toothpaste constituents. Once ingested, exogenous microparticles are unlikely to pass through the gastrointestinal tract without adsorbing to their surfaces some ions and molecules of the intestinal lumen. Both entropy and ionic attraction drive such interactions. Calcium ions are especially well adsorbed by dietary microparticles which then provide a positively charged surface for the attraction (adsorption) of other organic molecules such as lipopolysaccharides, peptidoglycans or protein antigen from the diet or commensal flora. The major (but not only) sites of microparticle entry into intestinal tissue are the M-cell rich lymphoid aggregates (termed Peyer's patches in the small bowel). Indeed, it is well established that this is an efficient transport route for non-biological microparticles although it is unclear why. We hypothesise that this pathway exists for "endogenous microparticles" of calcium phosphate, with immunological and physiological benefit, and that "exogenous dietary microparticles", such as titanium dioxide and the silicates, hijack this route. This overview focuses on what is known of these microparticles and outlines their potential role in immune tolerance of the gut (endogenous microparticles) or immune activation (exogenous microparticles) and inflammation of the gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.