ArticleEuropean journal of nuclear medicine and molecular imaging2008
Variations in 123I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: a need for standardisation and validation.
Article in European journal of nuclear medicine and molecular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology.European journal of nuclear medicine and molecular imaging · 2010Guideline
- Relationship of left ventricular global longitudinal strain with cardiac autonomic denervation as assessed byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Trial
- How to best appreciate the possible clinical role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Imaging cardiac sympathetic innervation with MIBG: linear conversion of the heart-to-mediastinum ratio between different collimators.EJNMMI physics · 2019Article
- A European myocardialJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and CardiacInternational journal of endocrinology · 2018Article
- Cross calibration ofAnnals of nuclear medicine · 2017Article
- Cardiac sympathetic nervous system imaging withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Standardization ofClinical and translational imaging · 2017Review
- (123)I-Meta-iodobenzylguanidine Sympathetic Imaging: Standardization and Application to Neurological Diseases.Chonnam medical journal · 2016Review
- Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database.Annals of nuclear medicine · 2016Review
- Individuals with impaired glucose tolerance demonstrate normal cardiac sympathetic innervation using I-123 mIBG scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Quantification of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratios: not so simple after all.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Impact of a predefined mediastinal ROI on inter-observer variability of planar ¹²³I-MIBG heart-to-mediastinum ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Septal penetration in iodine-123 metaiodobenzylguanidine cardiac sympathetic imaging using a medium-energy collimator.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- I -123 metaiodobenzylguanidine imaging for predicting ventricular arrhythmia in heart failure patients.Journal of biomedical research · 2013Review
- Influence of myocardial region of interest definition on quantitative analysis of planar 123I-mIBG images.European journal of nuclear medicine and molecular imaging · 2013Article
- Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure.European journal of nuclear medicine and molecular imaging · 2012Article
- Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study.European journal of nuclear medicine and molecular imaging · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is lack of validation and standardisation of acquisition parameters for myocardial (123)I-metaiodobenzylguanidine (MIBG). This lack of standardisation hampers large scale implementation of (123)I-MIBG parameters in the evaluation of patients with chronic heart failure (CHF).
methodsIn a retrospective multi-centre study (123)I-MIBG planar scintigrams obtained on 290 CHF patients (82% male; 58% dilated cardiomyopathy; New York Heart Association [NYHA classification] > I) were reanalysed to determine the late heart-to-mediastinum ratio (H/M).
resultsThere was a large variation in acquisition parameters. Multivariate forward stepwise regression showed that a significant proportion (31%, p < 0.001) of the variation in late H/M could be explained by a model containing patient-related variables and acquisition parameters. Left ventricular ejection fraction (p < 0.001), type of collimation (p < 0.001), acquisition duration (p = 0.001), NYHA class (p = 0.028) and age (p = 0.034) were independent predictors of late H/M.
conclusionsAcquisitions parameters are independent contributors to the variation of semi-quantitative measurements of cardiac (123)I-MIBG uptake. Improved standardisation of cardiac (123)I-MIBG imaging parameters would contribute to increased clinical applicability for this procedure.
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