ArticleBioinformatics (Oxford, England)2007
Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes.
Article in Bioinformatics (Oxford, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Disease signatures are robust across tissues and experiments.Molecular systems biology · 2009Pooled it
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- In silico methods for drug repurposing and pharmacology.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
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- Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.PLoS genetics · 2014Article
- Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.Human genetics · 2013Article
- Systems Biology Approaches and Applications in Obesity, Diabetes, and Cardiovascular Diseases.Current cardiovascular risk reports · 2013Article
- Predicting disease-related subnetworks for type 1 diabetes using a new network activity score.Omics : a journal of integrative biology · 2012Article
- Molecular signatures from omics data: from chaos to consensus.Biotechnology journal · 2012Review
- Identifying common genes and networks in multi-organ fibrosis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2012Article
- An automated bayesian framework for integrative gene expression analysis and predictive medicine.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2012Article
- Leveraging domain information to restructure biological prediction.BMC bioinformatics · 2011Article
- Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes.BMC gastroenterology · 2011Article
- Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants.BMC bioinformatics · 2010Article
- Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
motivationGenome-wide experiments only rarely show resounding success in yielding genes associated with complex polygenic disorders. We evaluate 49 obesity-related genome-wide experiments with publicly available findings including microarray, genetics, proteomics and gene knock-down from human, mouse, rat and worm, in terms of their ability to rediscover a comprehensive set of genes previously found to be causally associated or having variants associated with obesity.
resultsIndividual experiments show poor predictive ability for rediscovering known obesity-associated genes. We show that intersecting the results of experiments significantly improves the sensitivity, specificity and precision of the prediction of obesity-associated genes. We create an integrative model that statistically significantly outperforms all 49 individual genome-wide experiments. We find that genes known to be associated with obesity are significantly implicated in more obesity-related experiments and use this to provide a list of genes that we predict to have the highest likelihood of association for obesity. The approach described here can include any number and type of genome-wide experiments and might be useful for other complex polygenic disorders as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.