ArticleApplied and environmental microbiology2007
Metagenomic characterization of Chesapeake Bay virioplankton.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 214 citations in OpenAlex.
- Prokaryotic Molecular Defense Mechanisms and Their Potential Applications in Cancer Biology: A Special Consideration for Cyanobacterial Systems.Current issues in molecular biology · 2026Review
- Environmental gradients shape viral-host dynamics in the Pearl River estuary.ISME communications · 2025Article
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- MCRL: using a reference library to compress a metagenome into a non-redundant list of sequences, considering viruses as a case study.Bioinformatics (Oxford, England) · 2022Article
- Interaction dynamics and virus-host range for estuarine actinophages captured by epicPCR.Nature microbiology · 2021Article
- Uncultivated Viral Populations Dominate Estuarine Viromes on the Spatiotemporal Scale.mSystems · 2021Article
- RNA Viruses in Aquatic Unicellular Eukaryotes.Viruses · 2021Review
- Quantification of T4-Like and T7-Like Cyanophages Using the Polony Method Show They Are Significant Members of the Virioplankton in the North Pacific Subtropical Gyre.Frontiers in microbiology · 2020Article
- Cobaviruses - a new globally distributed phage group infecting Rhodobacteraceae in marine ecosystems.The ISME journal · 2019Article
- Isolation, characterization and analysis of bacteriophages from the haloalkaline lake Elmenteita, Kenya.PloS one · 2019Article
- Genetic and functional diversity of double-stranded DNA viruses in a tropical monsoonal estuary, India.Scientific reports · 2018Article
- Genetic Diversity and Cooccurrence Patterns of Marine Cyanopodoviruses and Picocyanobacteria.Applied and environmental microbiology · 2018Article
- Unprecedented Diversity of ssDNA Phages from the FamilyViruses · 2018Article
- Family A DNA Polymerase Phylogeny Uncovers Diversity and Replication Gene Organization in the Virioplankton.Frontiers in microbiology · 2018Article
- Agricultural Freshwater Pond Supports Diverse and Dynamic Bacterial and Viral Populations.Frontiers in microbiology · 2018Article
- Occurrence and seasonal dynamics of RNA viral genotypes in three contrasting temperate lakes.PloS one · 2018Article
- Assessing Species Diversity Using Metavirome Data: Methods and Challenges.Computational and structural biotechnology journal · 2017Review
- Seasonal Dynamics and Metagenomic Characterization of Marine Viruses in Goseong Bay, Korea.PloS one · 2017Article
- Transcriptome dynamics of a broad host-range cyanophage and its hosts.The ISME journal · 2016Article
- Environmental Viral Metagenomics Analyses in Aquaculture: Applications in Epidemiology and Disease Control.Frontiers in microbiology · 2016Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses are ubiquitous and abundant throughout the biosphere. In marine systems, virus-mediated processes can have significant impacts on microbial diversity and on global biogeocehmical cycling. However, viral genetic diversity remains poorly characterized. To address this shortcoming, a metagenomic library was constructed from Chesapeake Bay virioplankton. The resulting sequences constitute the largest collection of long-read double-stranded DNA (dsDNA) viral metagenome data reported to date. BLAST homology comparisons showed that Chesapeake Bay virioplankton contained a high proportion of unknown (homologous only to environmental sequences) and novel (no significant homolog) sequences. This analysis suggests that dsDNA viruses are likely one of the largest reservoirs of unknown genetic diversity in the biosphere. The taxonomic origin of BLAST homologs to viral library sequences agreed well with reported abundances of cooccurring bacterial subphyla within the estuary and indicated that cyanophages were abundant. However, the low proportion of Siphophage homologs contradicts a previous assertion that this family comprises most bacteriophage diversity. Identification and analyses of cyanobacterial homologs of the psbA gene illustrated the value of metagenomic studies of virioplankton. The phylogeny of inferred PsbA protein sequences suggested that Chesapeake Bay cyanophage strains are endemic in that environment. The ratio of psbA homologous sequences to total cyanophage sequences in the metagenome indicated that the psbA gene may be nearly universal in Chesapeake Bay cyanophage genomes. Furthermore, the low frequency of psbD homologs in the library supports the prediction that Chesapeake Bay cyanophage populations are dominated by Podoviridae.
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