ArticleProceedings of the National Academy of Sciences of the United States of America2007
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- Transcriptionally active chromatin loops contain both 'active' and 'inactive' histone modifications that exhibit exclusivity at the level of nucleosome clusters.Epigenetics & chromatin · 2024Article
- Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group inFrontiers in cell and developmental biology · 2021Article
- Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator.Epigenetics & chromatin · 2019Article
- Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing.PLoS genetics · 2018Article
- Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus.Epigenetics & chromatin · 2017Article
- Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70.Epigenetics & chromatin · 2017Article
- An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.Molecular cell · 2016Article
- Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transcription through Polycomb response elements does not induce a switch from repression to activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The open for business model of the bithorax complex in Drosophila.Chromosoma · 2015Review
- Heat shock factor HSFB2a involved in gametophyte development of Arabidopsis thaliana and its expression is controlled by a heat-inducible long non-coding antisense RNA.Plant molecular biology · 2014Article
- High-resolution mapping defines the cooperative architecture of Polycomb response elements.Genome research · 2014Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes.PLoS genetics · 2013Article
- Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin.Nucleic acids research · 2013Article
- Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.PloS one · 2013Article
- PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C.PLoS genetics · 2013Article
- TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.Cell · 2012Article
- A polycomb group protein is retained at specific sites on chromatin in mitosis.PLoS genetics · 2012Article
- RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function.Genes & development · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila Polycomb group (PcG) and Trithorax group (TrxG) proteins are responsible for the maintenance of stable transcription patterns of many developmental regulators, such as the homeotic genes. We have used ChIP-on-chip to compare the distribution of several PcG/TrxG proteins, as well as histone modifications in active and repressed genes across the two homeotic complexes ANT-C and BX-C. Our data indicate the colocalization of the Polycomb repressive complex 1 (PRC1) with Trx and the DNA binding protein Pleiohomeotic (Pho) at discrete sequence elements as well as significant chromatin assembly differences in active and inactive regions. Trx binds to the promoters of active genes and noncoding transcripts. Most strikingly, in the active state, Pho covers extended chromatin domains over many kilobases. This feature of Pho, observed on many polytene chromosome puffs, reflects a previously undescribed function. At the hsp70 gene, we demonstrate in mutants that Pho is required for transcriptional recovery after heat shock. Besides its presumptive function in recruiting PcG complexes to their site of action, our results now uncover that Pho plays an additional role in the repression of already induced genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.