ArticleBiophysical journal2008
Decoding of calcium oscillations by phosphorylation cycles: analytic results.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Differential regulation of calcium-activated plant kinases in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2025Article
- The Hill-Type Equation Reveals the Regulatory Principle of Target Protein Expression Led by p53 Pulsing.FASEB bioAdvances · 2025Article
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
- Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields.Nanoscale advances · 2024Article
- Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.Frontiers in network physiology · 2024Review
- Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.Journal of bone and mineral metabolism · 2023Article
- X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation.The Journal of general physiology · 2022Article
- Decoding the Bell-Shaped Calcium Spikes in Phosphorylation Cycles of Flagella.International journal of molecular sciences · 2022Article
- A Hill type equation can predict target gene expression driven by p53 pulsing.FEBS open bio · 2021Article
- The Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction.iScience · 2020Article
- CaBiophysical journal · 2020Article
- IPiScience · 2020Article
- Differential equation-based minimal model describing metabolic oscillations inRoyal Society open science · 2020Article
- Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines.Biophysical journal · 2019Article
- On Information Extraction and Decoding Mechanisms Improved by Noisy Amplification in Signaling Pathways.Scientific reports · 2019Article
- Systems and synthetic biology approaches in understanding biological oscillators.Quantitative biology (Beijing, China) · 2018Article
- Understanding non-linear effects from Hill-type dynamics with application to decoding of p53 signaling.Scientific reports · 2018Article
- Validation of electrical stimulation models: intracellular calcium measurement in three-dimensional scaffolds.Journal of neurophysiology · 2017Article
- Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity.Trends in biotechnology · 2017Review
- Optogenetic Control of Calcium Oscillation Waveform Defines NFAT as an Integrator of Calcium Load.Cell systems · 2016Article
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3 authors.
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Abstract
Experimental studies have demonstrated that Ca(2+)-regulated proteins are sensitive to the frequency of Ca(2+) oscillations, and several mathematical models for specific proteins have provided insight into the mechanisms involved. Because of the large number of Ca(2+)-regulated proteins in signal transduction, metabolism and gene expression, it is desirable to establish in general terms which molecular properties shape the response to oscillatory Ca(2+) signals. Here we address this question by analyzing in detail a model of a prototypical Ca(2+)-decoding module, consisting of a target protein whose activity is controlled by a Ca(2+)-activated kinase and the counteracting phosphatase. We show that this module can decode the frequency of Ca(2+) oscillations, at constant average Ca(2+) signal, provided that the Ca(2+) spikes are narrow and the oscillation frequency is sufficiently low--of the order of the phosphatase rate constant or below. Moreover, Ca(2+) oscillations activate the target more efficiently than a constant signal when Ca(2+) is bound cooperatively and with low affinity. Thus, the rate constants and the Ca(2+) affinities of the target-modifying enzymes can be tuned in such a way that the module responds optimally to Ca(2+) spikes of a certain amplitude and frequency. Frequency sensitivity is further enhanced when the limited duration of the external stimulus driving Ca(2+) signaling is accounted for. Thus, our study identifies molecular parameters that may be involved in establishing the specificity of cellular responses downstream of Ca(2+) oscillations.
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