Evidence map›Paper›PMID 17921211›Full record

ArticleBiophysical journal2008

Response to Bianco et al.: Interaction forces between F-actin and titin PEVK domain measured with optical tweezers.

Kenneth S Campbell, Martin Lakie

Open access · bronzeAbstract readComment
In one paragraph

Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Short-range mechanical properties of skeletal and cardiac muscles.Advances in experimental medicine and biology · 2010
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kenneth S CampbellDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA. k.s.campbell@uky.edu
Martin Lakie
University of Birmingham · GBUniversity of Kentucky · US

Funding

Myocardial Stiffness in Aging Associated Diastolic Heart FailureR03AG028162 · NIA · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S · 2006 to 2007
$118k
NIA NIH HHS AG028162NIA NIH HHS R03 AG028162
6 · The paper itself

Abstract

A recent publication in Biophysical Journal by Bianco et al. ("Interaction forces between F-actin and titin PEVK domain measured with optical tweezers") shows that the PEVK domain of titin molecules interacts with F-actin. This newly discovered behavior could influence the mechanical properties of striated muscles, and Bianco et al. suggest that the interactions between actin and titin could modulate thixotropic behavior. In this Comment to the Editor, we suggest that the thixotropic properties of striated muscles in vivo are more likely to reflect dynamic changes in the proportion of myosin cross-bridges bound between the myofilaments.

Indexed as

ActinsAnimalsBiomechanical PhenomenaBiophysical PhenomenaBiophysicsConnectinHumansMuscle ContractionMuscle ProteinsNanotechnologyOptical TweezersOsmolar ConcentrationPeptide FragmentsProtein BindingProtein KinasesProtein Structure, TertiaryActinsConnectinMuscle ProteinsPeptide FragmentsProtein KinasesRecombinant ProteinsTTN protein, human

Identifiers

PMID17921211
PMCPMC2134857
OpenAlexW2052486720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.