Evidence map›Paper›PMID 17921044›Full record

ReviewCurrent opinion in microbiology2007

Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power.

Herminia de Lencastre, Duarte Oliveira, Alexander Tomasz

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 279 citations in OpenAlex.

  1. Review
  2. Antimicrobial activity of bacterial endophytes isolated from Aconitum nagarum Stapf ,a medicinal plant of North East Indo-Burma belt.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. Article
  4. From colonizer to culprit: genomic and clinical insights into S. epidermidis from post-surgical endophthalmitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  5. Journal of bacteriology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Assessment of Antibacterial Efficacy ofArchives of Razi Institute · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Prevalence and Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Review
  20. Constructing and deconstructing the bacterial cell wall.Protein science : a publication of the Protein Society · 2020
    Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Herminia de LencastreLaboratory of Microbiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Duarte Oliveira
Alexander Tomasz
Rockefeller University · USUniversidade Nova de Lisboa · PT

Funding

S.AUREUS CELL WALLS AND DRUG RESISTANCE IN MRSA AND VRSAR01AI045738 · NIAID · ROCKEFELLER UNIVERSITY · PI TOMASZ, ALEXANDER · 2000 to 2014
$8.5M
NIAID NIH HHS 2 RO1 AI045738-08NIAID NIH HHS R01 AI045738
6 · The paper itself

Abstract

Nothing documents better the spectacular adaptive capacity of Staphylococcus aureus than the response of this important human and animal pathogen to the introduction of antimicrobial agents into the clinical environment. The effectiveness of penicillin introduced in the early 1940s was virtually annulled within a decade because of the plasmid epidemics that spread the ss-lactamase gene through the entire species of S. aureus. In 1960 within one to two years of the introduction of penicillinase resistant ss-lactams (methicillin), methicillin resistant S. aureus (MRSA) strains were identified in clinical specimens. By the 1980s, epidemic clones of MRSA acquired multidrug resistant traits and spread worldwide to become one of the most important causative agents of hospital acquired infections. In the early 2000s, MRSA strains carrying the Tn1546 transposon-based enterococcal vancomycin resistant mechanism were identified in clinical specimens, bringing the specter of a totally resistant bacterial pathogen closer to reality. Then, in the late 1990s, just as effective hygienic and antibiotic use policies managed to bring down the frequency of MRSA in hospitals of several countries, MRSA strains began to show up in the community.

Indexed as

Adaptation, BiologicalBacterial ProteinsBacterial Typing TechniquesChromosomes, BacterialCommunity-Acquired InfectionsDrug Resistance, Multiple, BacterialEvolution, MolecularMethicillin ResistancePenicillin-Binding ProteinsStaphylococcal InfectionsStaphylococcus aureusBacterial ProteinsmecA protein, Staphylococcus aureusPenicillin-Binding Proteins

Identifiers

PMID17921044
PMCPMC2701899
OpenAlexW2038000091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.