ReviewMolecular immunology2008
Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.
Review in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines.Immunological reviews · 2025Review
- How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.Nature communications · 2022Article
- Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.The Journal of experimental medicine · 2017Article
- A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).Cellular and molecular life sciences : CMLS · 2014Review
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- On the logic of restrictive recognition of peptide by the T-cell antigen receptor.Immunologic research · 2011Article
- Accelerated thymocyte maturation in IL-12Rβ2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination.Experimental and molecular pathology · 2010Article
- Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Cold Spring Harbor perspectives in biology · 2010Review
- Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.Protein science : a publication of the Protein Society · 2009Article
- The T-cell receptor repertoire of regulatory T cells.Immunology · 2008Review
- TCR-MHC docking orientation: natural selection, or thymic selection?Immunologic research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.