ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2007
HLA DQ gene dosage and risk and severity of celiac disease.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening.World journal of gastroenterology · 2020Pooled it
- Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.PloS one · 2019Pooled it
- Trial
- The clinical utility of exome sequencing for risk stratification in celiac disease.Journal of human immunity · 2026Article
- Gene, genetics and genetic medicines in gastroenterology: Current status and its future.World journal of gastroenterology · 2026Review
- Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity.Frontiers in molecular medicine · 2025Article
- Association of HLA-DQ4/5 genotype polymorphisms with celiac disease in a group of children in Southwest Iran: A case-control study.Health science reports · 2024Article
- IgA nephropathy.Nature reviews. Disease primers · 2023Review
- Cytological, molecular, cytogenetic, and physiological characterization of a novel immortalized human enteric glial cell line.Frontiers in cellular neuroscience · 2023Article
- The Evolving Landscape of Biomarkers in Celiac Disease: Leading the Way to Clinical Development.Frontiers in immunology · 2021Review
- Article
- Refractory Celiac Disease Type II: A Case Report and Literature Review.Frontiers in medicine · 2020Article
- Community-Based Study of Celiac Disease Autoimmunity Progression in Adults.Gastroenterology · 2020Article
- Influence of HLA on clinical and analytical features of pediatric celiac disease.BMC gastroenterology · 2019Observational
- The Liver and Celiac Disease.Clinics in liver disease · 2019Review
- Towards an individual screening strategy for first-degree relatives of celiac patients.European journal of pediatrics · 2018Article
- HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation.BMC gastroenterology · 2018Article
- HLA Typing and Celiac Disease in Moroccans.Medical sciences (Basel, Switzerland) · 2017Article
- Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.European journal of human genetics : EJHG · 2016Article
- Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease.Autoimmune diseases · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsCeliac disease (CD) is a chronic inflammatory disorder of the small intestine that is strongly associated with certain HLA molecules encoded by DQA and DQB genes. The aim of this study was to examine the role of DQA and DQB alleles in determining the risk for and the age of onset and severity of CD in an American population.
methodsHigh-resolution class 2 HLA genotyping was performed in a population-based sample (n = 84) of southeastern Minnesota residents with CD and a comparable control group (n = 102) to determine the contribution of DQA and DQB alleles to disease risk. Logistic regression modeling was used to examine the relative and absolute risks of CD.
resultsNinety-seven percent of CD patients carried both of the HLA alleles, DQA1*05 and DQB1*02. Those who carried a second allele of DQB1*02 were 5 times more likely to have CD than those with just one (95% confidence interval, 1.4-18.1). The carriage of 2 copies of DQB1*02 did not predict either an earlier age of onset or severity of disease.
conclusionsBoth HLA alleles DQA1*05 and DQB1*02 are associated with a greatly increased risk of CD, although the latter has the greater effect. Carrying 2 copies of DQB1*02 was associated with an even greater risk for disease but did not predict an earlier age of onset and diagnosis or disease severity. Assessing the copy number of the DQB1*02 allele might allow for the stratification of disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.