ArticleThe international journal of biochemistry & cell biology2008
Amino acid transport through the Saccharomyces cerevisiae Gap1 permease is controlled by the Ras/cAMP pathway.
Article in The international journal of biochemistry & cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- A multi-omics systems toxicology framework reveals amino acid-mediated stress adaptation to deltamethrin exposure in a yeast model.Scientific reports · 2026Article
- The structure-dependent effects of newly synthesised cationic gemini surfactants against yeast cells.Scientific reports · 2025Article
- Article
- Role ofFrontiers in bioengineering and biotechnology · 2020Article
- Nutrient and Stress Sensing in Pathogenic Yeasts.Frontiers in microbiology · 2019Review
- Purification and characterization of a novel glutamate dehydrogenase from Geotrichum candidum with higher alcohol and amino acid activity.AMB Express · 2017Article
- Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.PLoS genetics · 2014Article
- From transporter to transceptor: signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Article
- Ras signaling in yeast.Genes & cancer · 2011Article
- Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system.Molecular biology of the cell · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The general amino acid permease (Gap1p) of Saccharomyces cerevisiae is a broad range, low affinity permease that imports amino acids in cells growing on poor nitrogen sources. This permease also signals the presence of amino acids through the fermentable growth medium pathway allowing the cell to respond to new sources of nitrogen in the surrounding medium. Yeast with an activated Ras2/cAMP pathway show many phenotypes indicative of altered nitrogen uptake and metabolism; sensitivity to nitrogen starvation, low amino acid pools. We have shown that Gap1p activity is lowered in cells with an activated RAS2(val19) allele or elevated cAMP levels whereas cells with inactive ras2 allele lose ammonia repression of Gap1p-mediated transport. This regulation is through a post-transcriptional mechanism; transcription of GAP1 is not affected by cAMP level. A mechanism by which the Ras2/cAMP/PKA pathway controls the ubiquitin-dependent degradation of Gap1p is most consistent with the data.
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Registered trials
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