ReviewSeminars in cell & developmental biology2007
The role of insulator elements in large-scale chromatin structure in interphase.
Review in Seminars in cell & developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Nuclear architecture and the structural basis of mitotic memory.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.PLoS genetics · 2022Article
- The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains.Cell reports · 2020Article
- Ectopically tethered CP190 induces large-scale chromatin decondensation.Scientific reports · 2014Article
- Human tRNA genes function as chromatin insulators.The EMBO journal · 2012Article
- Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain.PLoS genetics · 2012Article
- tRNA genes protect a reporter gene from epigenetic silencing in mouse cells.Cell cycle (Georgetown, Tex.) · 2011Article
- The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation.PLoS genetics · 2011Article
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- Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure.Nucleic acids research · 2010Article
- Prediction of nucleosome DNA formation potential and nucleosome positioning using increment of diversity combined with quadratic discriminant analysis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
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- High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.The EMBO journal · 2010Article
- Drosophila SAF-B links the nuclear matrix, chromosomes, and transcriptional activity.PloS one · 2010Article
- Chromatin boundaries, insulators, and long-range interactions in the nucleus.Cold Spring Harbor symposia on quantitative biology · 2010Article
- A chromatin insulator mediates transgene homing and very long-range enhancer-promoter communication.Development (Cambridge, England) · 2009Article
- Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity.Current genomics · 2009Article
- Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.PloS one · 2009Article
- Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization.Developmental biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Insulator elements can be classified as enhancer-blocking or barrier insulators depending on whether they interfere with enhancer-promoter interactions or act as barriers against the spreading of heterochromatin. The former class may exert its function at least in part by attaching the chromatin fiber to a nuclear substrate such as the nuclear matrix, resulting in the formation of chromatin loops. The latter class functions by recruiting histone-modifying enzymes, although some barrier insulators have also been shown to create chromatin loops. These loops may correspond to functional nuclear domains containing clusters of co-expressed genes. Thus, insulators may determine specific patterns of nuclear organization that are important in establishing specific programs of gene expression during cell differentiation and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.