ArticleNeuroscience2007
Corticotropin releasing factor-1 receptor antagonist, CP-154,526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Corticotropin-Releasing Factor (CRF) and Addictive Behaviors.International review of neurobiology · 2017Review
- An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence.Frontiers in endocrinology · 2016Review
- Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation.Genes, brain, and behavior · 2015Review
- Histone acetylation in the nucleus accumbens shell modulates ethanol-induced locomotor activity in DBA/2J mice.Alcoholism, clinical and experimental research · 2014Article
- Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects.Homeopathy : the journal of the Faculty of Homeopathy · 2013Article
- Positive allosteric modulation of the GABA(B) receptor by GS39783 attenuates the locomotor stimulant actions of ethanol and potentiates the induction of locomotor sensitization.Alcohol (Fayetteville, N.Y.) · 2012Article
- Role of corticotropin-releasing factor and corticosterone in behavioral sensitization to ethanol.The Journal of pharmacology and experimental therapeutics · 2012Article
- Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice.Addiction biology · 2012Article
- Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice.PloS one · 2012Article
- Insulin attenuates the acquisition and expression of ethanol-induced locomotor sensitization in DBA/2J mice.Life sciences · 2011Article
- Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention.CNS drugs · 2011Review
- Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.Behavioural brain research · 2010Article
- Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleManipulation of glucocorticoid receptor signaling has been shown to alter the acquisition and expression of ethanol-induced locomotor sensitization in mice. It is unknown if other components of the hypothalamic-pituitary-adrenal (HPA)-axis modulate locomotor sensitization resulting from repeated ethanol administration. In the present investigation, we determined if pretreatment with an i.p. injection of CP-154,526, a selective corticotropin releasing factor (CRF) type-1 receptor antagonist, would block the acquisition and/or expression of ethanol-induced locomotor sensitization in male DBA/2J mice.
methodsTo assess the role of the CRF1 receptor in the acquisition of behavioral sensitization, mice were pretreated with an i.p. injection of CP-154,526 30 min before each of 10 sensitizing i.p. injections of ethanol. To determine the role of the CRF1 receptor in modulating the expression of ethanol-induced sensitization, mice that had previously been sensitized to the locomotor stimulant effects of ethanol were pretreated with CP-154,526 30 min before an i.p. injection of ethanol on the test day. In a third study, ethanol-naïve mice were pretreated with CP-154,526 30 min before an initial i.p. injection of ethanol to determine the combined effects of the CRF1 receptor antagonist and ethanol on locomotor activity. Blood ethanol concentrations were assessed at the termination of sensitization studies.
resultsPretreatment with CP-154,526 blocked the expression of ethanol-induced locomotor sensitization in DBA/2J mice but did not prevent the acquisition of sensitization. The ability of CP-154,526 to block the expression of ethanol-induced locomotor sensitization was not attributable to alterations in blood ethanol levels or possible sedative effects produced by the combined administration of CP-154,526 and ethanol.
conclusionsThese data provide novel evidence that CRF1 receptor signaling modulates the expression of ethanol-induced locomotor sensitization, and add to a growing literature suggesting a role for neurochemicals and hormones associated with the HPA-axis in behavioral sensitization resulting from repeated exposure to drugs of abuse.
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