ArticleBiochimica et biophysica acta2008
Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae.
Article in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer.Acta pharmaceutica Sinica. B · 2024Article
- PpAKR1A, a Novel Aldo-Keto Reductase from Physcomitrella Patens, Plays a Positive Role in Salt Stress.International journal of molecular sciences · 2019Article
- Adaptation of the secretome of Echinostoma caproni may contribute to parasite survival in a Th1 milieu.Parasitology research · 2018Article
- Differential Proteome Analysis of a Flor Yeast Strain under Biofilm Formation.International journal of molecular sciences · 2017Article
- Article
- Disulfide proteomics of rice cultured cells in response to OsRacl and probenazole-related immune signaling pathway in rice.Proteome science · 2016Article
- Quantitative evaluation of aldo-keto reductase expression in hepatocellular carcinoma (HCC) cell lines.Genomics, proteomics & bioinformatics · 2013Article
- Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature.BMC microbiology · 2013Article
- Microbial gutta-percha degradation shares common steps with rubber degradation by Nocardia nova SH22a.Applied and environmental microbiology · 2013Article
- Overexpression of aldo-keto-reductase in azole-resistant clinical isolates of Candida glabrata determined by cDNA-AFLP.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags.BMC research notes · 2012Article
- Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.Molecular genetics and genomics : MGG · 2011Article
- Expression profiling of Crambe abyssinica under arsenate stress identifies genes and gene networks involved in arsenic metabolism and detoxification.BMC plant biology · 2010Article
- TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen.PLoS pathogens · 2009Article
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2 authors at 1 institution in 1 country.
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Abstract
A large family of aldo-keto reductases with similar kinetic and structural properties but unknown physiological roles is expressed in the yeast Saccharomyces cerevisiae. Strains with one or two AKR genes disrupted have apparently normal phenotypes, but disruption of at least three AKR genes results in a heat shock phenotype and slow growth in inositol-deficient culture medium (Ino(-)). The present study was carried out to identify metabolic or signaling defects that may underlie phenotypes that emerge in AKR deficient strains. Here we demonstrate that pretreatment of a pentuple AKR null mutant with the anti-oxidative agent N-acetyl-cysteine rescues the heat shock phenotype. This indicates that AKR gene disruption may be associated with defects in oxidative stress response. We observed additional markers of oxidative stress in AKR-deficient strains, including reduced glutathione levels, constitutive nuclear localization of the oxidation-sensitive transcription factor Yap1 and upregulation of a set of Yap1 target genes whose function as a group is primarily involved in response to oxidative stress and redox balance. Genetic analysis of the Ino(-) phenotype of the null mutants showed that defects in transcriptional regulation of the INO1, which encodes for inositol-1-phosphate synthase, can be rescued through ectopic expression of a functional INO1. Taken together, these results suggest potential roles for AKRs in oxidative defense and transcriptional regulation.
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