ArticleDevelopmental biology2007
Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Extraocular muscle satellite cells are high performance myo-engines retaining efficient regenerative capacity in dystrophin deficiency.Developmental biology · 2015Article
- Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration.Frontiers in aging neuroscience · 2015Article
- Competence of in vitro cultured mouse embryonic stem cells for myogenic differentiation and fusion with myoblasts.Stem cells and development · 2014Article
- Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy.Journal of molecular and cellular cardiology · 2013Article
- Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Article
- A contemporary atlas of the mouse diaphragm: myogenicity, vascularity, and the Pax3 connection.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- The skeletal muscle satellite cell: still young and fascinating at 50.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Characterization of Pax3-expressing cells from adult blood vessels.Journal of cell science · 2011Article
- The muscle satellite cell at 50: the formative years.Skeletal muscle · 2011Article
- Human epicardium-derived cells fuse with high efficiency with skeletal myotubes and differentiate toward the skeletal muscle phenotype: a comparison study with stromal and endothelial cells.Molecular biology of the cell · 2011Article
- Are human and mouse satellite cells really the same?The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
- Article
- Absence of CD34 on murine skeletal muscle satellite cells marks a reversible state of activation during acute injury.PloS one · 2010Article
- The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny.Developmental biology · 2010Article
- Noggin producing, MyoD-positive cells are crucial for eye development.Developmental biology · 2009Article
- Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Satellite cells are recognized as the main source for myoblasts in postnatal muscle. The possible participation of other cell types in myofiber maintenance remains a subject of debate. Here, we investigated the potential of vascular preparations from mouse retina to undergo myogenesis when cultured alone or with differentiated primary myogenic cultures. The choice of retina, an organ richly supplied with capillary network and anatomically separated from skeletal muscles, ensures that the vasculature preparation is devoid of satellite cells. We demonstrate that retina-derived cells spontaneously fuse with preexisting myotubes and contribute additional myonuclei, some of which initiate expression of muscle-specific genes after fusion. Myogenic differentiation of retinal cells prior to their fusion with preexisting myotubes was not detected. Although originating from vasculature preparations, nuclei undergoing myogenic reprogramming were contributed by cells that were neither endothelial nor blood borne. Our results suggest smooth muscle/pericytes as the possible source, and that myogenic reprogramming depends on the muscle specific transcription factor MyoD. Our studies provide insights into a novel avenue for myofiber maintenance, relying on nuclei of non-myogenic origin that undergo fusion and subsequent myogenic conversion within host myofibers. This process may support ongoing myofiber maintenance throughout life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.