ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2007
Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.
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100 citing papers in PubMed, 2 syntheses or guidelines pooled it, 225 citations in OpenAlex.
- Are adenoviruses zoonotic? A systematic review of the evidence.Emerging microbes & infections · 2019Pooled it
- Vaccines for the common cold.The Cochrane database of systematic reviews · 2017Pooled it
- Treatment of Severe Adenovirus Infection With HAdV-B21 in a Young Obese Male With Normal Immunity.Clinical case reports · 2025Article
- Investigating the impact of the COVID-19 pandemic on pediatric adenovirus infection patterns: a retrospective analysis.Microbiology spectrum · 2025Article
- Medical Comorbidities as the Independent Risk Factors of Severe Adenovirus Respiratory Tract Infection in Adults.Microorganisms · 2025Article
- Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- First identification of human adenovirus subtype 21a in Shenzhen, China with high-throughput sequencing.Frontiers in microbiology · 2025Article
- Research progress on human adenovirus sepsis.Frontiers in pediatrics · 2025Review
- Clinical and Radiological Features of an Adenovirus Type 7 Outbreak in Split-Dalmatia County, Croatia, 2022-2023.Pathogens (Basel, Switzerland) · 2024Article
- High-Frequency Recombination of Human Adenovirus in Children with Acute Respiratory Tract Infections in Beijing, China.Viruses · 2024Article
- Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases.PLoS neglected tropical diseases · 2023Article
- Factors Associated with Severe Adenovirus Pneumonia in Children: A Retrospective Study from Guangzhou, China (2017-2019).Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Molecular characterisation of human adenoviruses associated with respiratory infections in Uganda.BMC infectious diseases · 2023Article
- Risk Factors for the Development of Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Article
- Immunity to enteric viruses.Immunity · 2022Review
- Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber.Frontiers in microbiology · 2022Article
- Viral loads in nasopharyngeal aspirates and tracheal aspirates among children hospitalized with invasive ventilation for human adenovirus pneumonia.Virology journal · 2021Article
- Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang.Virology journal · 2021Article
- Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults.Viruses · 2021Review
40 more citing papers are in PubMed but not listed here.
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25 authors at 17 institutions in 1 country.
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Abstract
backgroundRecently, epidemiological and clinical data have revealed important changes with regard to clinical adenovirus infection, including alterations in antigenic presentation, geographical distribution, and virulence of the virus.
methodsIn an effort to better understand the epidemiology of clinical adenovirus infection in the United States, we adopted a new molecular adenovirus typing technique to study clinical adenovirus isolates collected from 22 medical facilities over a 25-month period during 2004-2006. A hexon gene sequence typing method was used to characterize 2237 clinical adenovirus-positive specimens, comparing their sequences with those of the 51 currently recognized prototype human adenovirus strains. In a blinded comparison, this method performed well and was much faster than the classic serologic typing method.
resultsAmong civilians, the most prevalent adenovirus types were types 3 (prevalence, 34.6%), 2 (24.3%), 1 (17.7%), and 5 (5.3%). Among military trainees, the most prevalent types were types 4 (prevalence, 92.8%), 3 (2.6%), and 21 (2.4%).
conclusionsFor both populations, we observed a statistically significant increasing trend of adenovirus type 21 detection over time. Among adenovirus isolates recovered from specimens from civilians, 50% were associated with hospitalization, 19.6% with a chronic disease condition, 11% with a bone marrow or solid organ transplantation, 7.4% with intensive care unit stay, and 4.2% with a cancer diagnosis. Multivariable risk factor modeling for adenovirus disease severity found that age <7 years (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.4-7.4), chronic disease (OR, 3.6; 95% CI, 2.6-5.1), recent transplantation (OR, 2.7; 95% CI, 1.3-5.2), and adenovirus type 5 (OR, 2.7; 95% CI, 1.5-4.7) or type 21 infection (OR, 7.6; 95% CI, 2.6-22.3) increased the risk of severe disease.
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