Evidence map›Paper›PMID 17917873›Full record

ReviewCritical reviews in biochemistry and molecular biology

Stress-induced mutagenesis in bacteria.

Patricia L Foster

Abstract readReview
In one paragraph

Review in Critical reviews in biochemistry and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

245 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cancer Evolvability Determines Therapy Outcomes.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. "Excluded phenotypes" restrict genetic paths toward adaptation in declining populations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Mutations and mitotic recombination events in nondividing cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Regulation of the Expression ofAntibiotics (Basel, Switzerland) · 2025
    Article
  18. Mitotic recombination events and single-base mutations induced by ultraviolet light in G1-arrested yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Article

185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Patricia L FosterDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA. plfoster@indiana.edu

Funding

Regulation of an Error-Prone PolymeraseR01GM065175 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI FOSTER, PATRICIA LORRAINE · 2002 to 2011
$2.0M
NIGMS NIH HHS GM065175NIGMS NIH HHS R01 GM065175
6 · The paper itself

Abstract

Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and survive these stresses, bacteria have global response systems that result in sweeping changes in gene expression and cellular metabolism. These responses are controlled by master regulators, which include: alternative sigma factors, such as RpoS and RpoH; small molecule effectors, such as ppGpp; gene repressors such as LexA; and, inorganic molecules, such as polyphosphate. The response pathways extensively overlap and are induced to various extents by the same environmental stresses. These stresses include nutritional deprivation, DNA damage, temperature shift, and exposure to antibiotics. All of these global stress responses include functions that can increase genetic variability. In particular, up-regulation and activation of error-prone DNA polymerases, down-regulation of error-correcting enzymes, and movement of mobile genetic elements are common features of several stress responses. The result is that under a variety of stressful conditions, bacteria are induced for genetic change. This transient mutator state may be important for adaptive evolution.

Indexed as

Adaptation, PhysiologicalGene Expression Regulation, BacterialBacterial ProteinsDNA DamageEscherichia coliHeat-Shock ResponseModels, BiologicalMutagenesisMutationOxidative StressPolyphosphatesSOS Response, GeneticsBacterial ProteinsPolyphosphates

Identifiers

PMID17917873
PMCPMC2747772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.