ArticleJournal of molecular evolution2007
Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues.
Article in Journal of molecular evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
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- The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians.iScience · 2025Article
- Genome-Wide Identification and Characterization ofInternational journal of molecular sciences · 2025Article
- Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression.Scientific reports · 2020Article
- Molecular basis of the digestive functionality in developing Persian sturgeon (Acipenser persicus) larvae: additional clues for its phylogenetic status.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Characterization and expression analyses of somatolactin-α and -β genes in rare minnows (Gobiocypris rarus) following waterborne cadmium exposure.Fish physiology and biochemistry · 2018Article
- Article
- Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL.Frontiers in endocrinology · 2018Article
- Novel Functional Role of NK3R Expression in the Potentiating Effects on Somatolactin α Autoregulation in grass carp pituitary cells.Scientific reports · 2016Article
- An ultra-high density linkage map and QTL mapping for sex and growth-related traits of common carp (Cyprinus carpio).Scientific reports · 2016Article
- Effect of diets enriched with rutin on blood parameters, oxidative biomarkers and pituitary hormone expression in silver catfish (Rhamdia quelen).Fish physiology and biochemistry · 2016Article
- GH, IGF-I and GH receptors mRNA expression in response to growth impairment following a food deprivation period in individually housed cichlid fish Cichlasoma dimerus.Fish physiology and biochemistry · 2015Article
- Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia.General and comparative endocrinology · 2014Review
- Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Article
- Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill.Molecular and cellular endocrinology · 2013Article
- Endocrine regulation of compensatory growth in fish.Frontiers in endocrinology · 2013Article
- Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains.BMC genetics · 2012Article
- Molecular and expression characterization of growth hormone/prolactin family genes in the Prenant's schizothoracin.Molecular biology reports · 2011Article
- ERK, Akt, and STAT5 are Differentially Activated by the Two Growth Hormone Receptor Subtypes of a Teleost Fish (Oncorhynchus Mykiss).Frontiers in endocrinology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two cognate hormones, growth hormone (GH) and somatolactin (SL), control several important physiological processes in vertebrates. Knowledge about GH and its receptor (GHR) has accumulated over the last decades. However, much less is known about SL and its receptor (SLR). SL is found only in fish (including lungfish), suggesting that it was present in the common ancestor of vertebrates, but was lost secondarily in the lineage leading to land vertebrates after the lungfish branched off. SLR was suggested to be a duplicated copy of GHR acquired only in teleosts via the fish-specific genome duplication (FSGD). This scenario (i.e., the existence of SL but not SLR in the vertebrate ancestors) is intriguing but contested. In this study, we first evaluated the plausibility of this scenario through synteny analyses and found that the loci for GHR and SLR are located in syntenic genomic positions, whereas the loci for GH and SL are not. Next, we cloned GHRs of lungfish and sturgeon, which possess SL but did not undergo the FSGD (i.e., they should not possess SLR). Their phylogenetic positions in the GHR/SLR gene tree further support the fish-specific scenario for the GHR-SLR duplication. Interestingly, their sequences share greater similarity with teleost SLRs and reptilian/amphibian GHRs than with the GHRs of mammals, birds, and teleosts. On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD.
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