ArticleJournal of molecular modeling2007
Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain.
Article in Journal of molecular modeling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
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- Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021.Virology journal · 2022Article
- Five Independent Cases of Human Infection with Avian Influenza H5N6 - Sichuan Province, China, 2021.China CDC weekly · 2021Article
- Molecular docking study of bio-inhibitors extracted from marine macro-alga Ulva fasciata against hemolysin protein of luminescence disease-causing Vibrio harveyi.Archives of microbiology · 2021Article
- Genetic Characteristics of Avian Influenza Virus Isolated from Wild Birds in South Korea, 2019-2020.Viruses · 2021Article
- NS1: A Key Protein in the "Game" Between Influenza A Virus and Host in Innate Immunity.Frontiers in cellular and infection microbiology · 2021Review
- Genetic Characterization of Avian Influenza A (H11N9) Virus Isolated from Mandarin Ducks in South Korea in 2018.Viruses · 2020Article
- Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.Nature communications · 2014Article
- The battle between influenza and the innate immune response in the human respiratory tract.Infection & chemotherapy · 2013Review
- Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation.ChemMedChem · 2012Article
- Accuracy of functional surfaces on comparatively modeled protein structures.Journal of structural and functional genomics · 2011Article
- Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.Antimicrobial agents and chemotherapy · 2010Article
- Structural and functional analysis of NS1 and NS2 proteins of H1N1 subtype.Genomics, proteomics & bioinformatics · 2010Article
- Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies.Bioorganic & medicinal chemistry · 2010Article
- The first low microM SecA inhibitors.Bioorganic & medicinal chemistry · 2010Article
- Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data.Journal of virology · 2009Article
- Computational studies of the binding site of alpha1A-adrenoceptor antagonists.Journal of molecular modeling · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Virulent H5N1 strains of influenza virus often harbor a D92E point mutation in the nonstructural protein NS1. This crucial mutation has been correlated with increased virulence and/or cytokine resistance, but the structural implications of such a change are still unclear. Furthermore, NS1 protein could also be a potential target for the development of novel antiviral agents against H5N1 strains. Therefore, a reasonable 3D model of H5N1 NS1 is important for the understanding of the molecular basis of increased virulence and the design of novel antiviral agents. Based on the crystal structure of a non-H5N1 NS1 protein, a model of H5N1 NS1 was developed by homology modeling, molecular mechanics and molecular dynamics simulations. It was found that the D92E mutation could result in weakened interactions of the carboxylate side chain with other phosphorylated residues, thereby activating phosphorylation of NS1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.