Trial reportJournal of thrombosis and thrombolysis2009
Effect of high dose statin therapy on platelet function; statins reduce aspirin-resistant platelet aggregation in patients with coronary heart disease.
Trial report in Journal of thrombosis and thrombolysis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Associations Between PFA-Measured Aspirin Resistance, Platelet Count, Renal Function, and Angiotensin Receptor Blockers.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients.Journal of vascular surgery · 2011Trial
- Statins and Hemostasis: Therapeutic Potential Based on Clinical Evidence.Advances in experimental medicine and biology · 2023Review
- Non-Lipid Effects of PCSK9 Monoclonal Antibodies on Vessel Wall.Journal of clinical medicine · 2022Review
- Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects.BioMed research international · 2021Review
- MexicanNutrients · 2020Article
- Clinical Impact of Hemorheology on Subclinical Myocardial Injury in Patients with Hypertension.Journal of clinical medicine research · 2018Article
- Association of Hemorheology With High-Sensitivity Cardiac Troponin T Levels in Patients With Type 2 Diabetes Mellitus Assessed by Microchannel Array Flow Analyzer.Cardiology research · 2017Article
- Establishing a predictive model for aspirin resistance in elderly Chinese patients with chronic cardiovascular disease.Journal of geriatric cardiology : JGC · 2016Article
- Simultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention.Clinical pharmacology : advances and applications · 2016Article
- Searching for factors associated with resistance to acetylsalicylic acid used for secondary prevention of stroke.Archives of medical science : AMS · 2015Article
- Resistance to acetylsalicylic acid in patients with type 2 diabetes mellitus is associated with lipid disorders and history of current smoking.Journal of endocrinological investigation · 2014Article
- Aspirin resistance in patients with type II diabetes mellitus.Upsala journal of medical sciences · 2014Article
- Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke.CNS drugs · 2010Review
- Clinical importance of aspirin and clopidogrel resistance.World journal of cardiology · 2010Article
- Prothrombinase formation at the site of microvascular injury and aspirin resistance: the effect of simvastatin.Thrombosis research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent evidence supports the preventive role of statins on platelet aggregation in patients with coronary heart disease.
aimOur aim was to determine the effects of aggressive statin therapy on platelet function in patients with coronary heart disease. MATERIAL AND
methodsA total of 178 consecutive patients (37-68 years old, 35.9% women) with stable coronary artery disease (CAD) was enrolled in the study. Platelet function assays were realized by the Platelet Function Analyzer (PFA)-100 with collagen and epinephrine (Col/Epi) and collagen and ADP (Col/ADP) cartridges. Aspirin resistance was defined as having a closure time (CT) of <186 s with Col/Epi cartridges despite regular aspirin therapy. A statin therapy protocol applied to the patients with aspirin resistance for 3 months.
resultsWe determined that 20 (11.2%) of patients had aspirin resistance by the PFA-100. Mean closure time measured with the Col/ADP cartridges was 83 +/- 18 s (53-162 s). Of the patients 12 were not on a statin therapy and eight were taking 10 mg daily atorvastatin. After 3 months of 40 mg daily atorvastatin therapy 13 subjects with aspirin resistance became aspirin sensitive by PFA-100 (P < 0.0001). There was also a significant decrease in total and LDL cholesterol levels and an increase in HDL cholesterol at the third month of statin therapy (P < 0.0001 for all).
conclusionStatin therapy reduced the in vitro aspirin resistance in 65% of the patients after a therapy of 3 months. Further studies are needed to elucidate the mechanism of statins' effects on platelet reactivity.
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