ArticleJournal of human genetics2007
Suggestive evidence for chromosomal localization of non-coding RNA from imprinted LIT1.
Article in Journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- RNA, Genome Output and Input.Frontiers in genetics · 2020Article
- The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.Epigenetics & chromatin · 2019Article
- Convergence in LINE-1 nucleotide variations can benefit redundantly forming triplexes with lncRNA in mammalian X-chromosome inactivation.Mobile DNA · 2019Article
- Regulation of functional KCNQ1OT1 lncRNA by β-catenin.Scientific reports · 2016Article
- Epigenesis and plasticity of mouse trophoblast stem cells.Cellular and molecular life sciences : CMLS · 2016Review
- Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review).Oncology letters · 2015Article
- From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.Endocrine reviews · 2015Review
- Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.The Journal of cell biology · 2014Article
- Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles.RNA (New York, N.Y.) · 2012Article
- Article
- The genomic binding sites of a noncoding RNA.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells.Development (Cambridge, England) · 2011Article
- Estrogen-mediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells.Carcinogenesis · 2011Article
- Monoallelic gene expression in mammals.Chromosoma · 2009Review
- The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing.Development (Cambridge, England) · 2009Article
- Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).Nature protocols · 2009Article
- Noncoding RNA in development.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Review
- Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-coding RNA LIT1/KCNQ1OT1, itself the product of an imprinted gene, is involved in cis-limited silencing within an imprinted cluster on human chromosome 11p15.5. Although the locus serves as an imprinting center, the mechanism of transcriptional regulation is not clear. To help understand the function of the LIT1 non-coding RNA, we used fluorescence in situ hybridization (FISH) to examine the sub-cellular localization of LIT1 RNA molecules. LIT1 RNA signals were observed in most of the interphase human lymphoblast and fibroblast cells. The RNA also appeared to accumulate on neighboring regions of chromatin containing the SLC22A18/IMPT1 and CDKN1C/p57KIP2 genes, as shown by high-resolution fiber RNA FISH and modified RNA TRAP (tagging and recovery of associated proteins) methods. These results suggest that LIT1 RNA stably localizes to a specific chromatin region and plays an important role in the transcriptional silencing of the imprinting domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.