ReviewStem cell reviews2007
Aging and the germ line: where mortality and immortality meet.
Review in Stem cell reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- A decline in follicle cell function is a major driver ofbioRxiv : the preprint server for biology · 2026Article
- The dissipation theory of aging: a quantitative analysis using a cellular aging map.npj aging · 2025Article
- Germline stem cell isolation, lineage tracing, and aging in a protochordate.bioRxiv : the preprint server for biology · 2025Article
- Remodeling, compartmentalization, and degradation: a trifecta for organelle quality control during gametogenesis.Current opinion in genetics & development · 2025Review
- A High-Throughput Method for QuantifyingToxics · 2024Article
- A high-throughput method for quantifyingbioRxiv : the preprint server for biology · 2024Article
- Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster.Biogerontology · 2024Article
- Transcriptional and mutational signatures of the Drosophila ageing germline.Nature ecology & evolution · 2023Article
- Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma ofScience advances · 2021Article
- Asymmetry, division of labour and the evolution of ageing in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Horizons in the evolution of aging.BMC biology · 2018Review
- Epigenetic regulation of ageing: linking environmental inputs to genomic stability.Nature reviews. Molecular cell biology · 2015Review
- Dual role of the caspase enzymes in satellite cells from aged and young subjects.Cell death & disease · 2013Article
- Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.Cell cycle (Georgetown, Tex.) · 2013Article
- Epigenetic regulation of aging stem cells.Oncogene · 2011Review
- Self-renewal of stem cells.Acta naturae · 2009Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Germ cells are highly specialized cells that form gametes, and they are the only cells within an organism that contribute genes to offspring. Germline stem cells (GSCs) sustain gamete production, both oogenesis (egg production) and spermatogenesis (sperm production), in many organisms. Since the genetic information contained within germ cells is passed from generation to generation, the germ line is often referred to as immortal. Therefore, it is possible that germ cells possess unique strategies to protect and transmit the genetic information contained within them indefinitely. However, aging often leads to a dramatic decrease in gamete production and fecundity. In addition, single gene mutations affecting longevity often have a converse effect on reproduction. Recent studies examining age-related changes in GSC number and activity, as well as changes to the stem cell microenvironment, provide insights into the mechanisms underlying the observed reduction in gametogenesis over the lifetime of an organism.
Indexed as
Identifiers
17917132What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.