ReviewMolecular neurobiology2007
Modulation of ligand-gated ion channels by antidepressants and antipsychotics.
Review in Molecular neurobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Haloperidol, a typical antipsychotic, inhibits 5-HTThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- Review
- RCSB Protein Data Bank: Enabling biomedical research and drug discovery.Protein science : a publication of the Protein Society · 2020Article
- Antidepressants are modifiers of lipid bilayer properties.The Journal of general physiology · 2019Article
- The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.Neuropharmacology · 2017Article
- Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders.Schizophrenia research and treatment · 2016Review
- Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments.Annals of the New York Academy of Sciences · 2015Review
- Mammalian sleep genetics.Neurogenetics · 2012Review
- Clinical pharmacology in sleep medicine.ISRN pharmacology · 2012Article
- The wake-promoting transmitter histamine preferentially enhances α-4 subunit-containing GABAA receptors.Neuropharmacology · 2011Article
- Article
- Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?BMC pharmacology · 2010Article
- Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve.British journal of pharmacology · 2009Article
- Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that antidepressants and antipsychotics mediate their therapeutic effects via specific interaction with processes related to synaptic neurotransmission in the central nervous system. Besides their well-known classical mechanisms of action, antidepressants and antipsychotics show widely unknown effects, which might also contribute to the pharmacological profile of these agents. There is growing evidence that an interaction of these drugs with allosteric modulatory sites of ligand-gated ion channels (LGICs) might represent a yet unknown principle of action. Such interactions of psychopharmacological drugs with LGICs might play an important role both for the therapeutic efficacy and the side effect profile of these agents. In this review, we focus on the direct interaction of antidepressants and antipsychotics with LGICs, which may provide a basis for the development of novel psychopharmacological drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.